Explores the mental, physical, cellular and biochemical aspects of environmental illnesses such as obesity, diabetes, chronic fatigue syndrome, PTSD, fibromyalgia, chemical sensitivities, neurological disorders and numerous others. We advocate for better access to medical care, healthier lifestyles, resource conservation and the use of assistance animals for the disabled to promote a better quality of life.
Friday, April 30, 2010
Short and Long Ter Vitamin Effects of Smoking
CiteULike: Long- and Short-term Effects of Tobacco Smoking on Circulating Concentrations of B Vitamins: "Ulvik, A., Ebbing, M., Hustad, S., Midttun, O., Nygard, O., Vollset, S. E., Bonaa, K. H., Nordrehaug, J. E., Nilsen, D. W., Schirmer, H., and Ueland, P. M. (2010). Long- and short-term effects of tobacco smoking on circulating concentrations of b vitamins. Clin Chem, 56(5):755-763."
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Thursday, April 29, 2010
PGC-1a and Exercise and Impact on Muscle Function and Insulin Sensitivity
"modest (~25%) upregulation of PGC-1alpha, within physiologic limits, does improve mitochondrial biogenesis, fatty acid oxidation and insulin sensitivity in healthy and insulin resistant skeletal muscle."
PGC-1{alpha} REGULATION BY EXERCISE TRAINING AND AND ITS INFLUENCES ON MUSCLE FUNCTION AND INSULIN SENSITIVITY [Am J Physiol Endocrinol Metab. 2010] - PubMed result:
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Wednesday, April 28, 2010
Scientists Discover Substance That Causes Pain
Scientists Discover Substance That Causes Pain: "a family of fatty acids called oxidized linoleic acid metabolites (OLAMs) play an important role in the biology of pain."
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'Epigenetic' Concepts Offer New Approach To Degenerative Disease
'Epigenetic' Concepts Offer New Approach To Degenerative Disease: "'Epigenetic' Concepts Offer New Approach To Degenerative Disease"
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Tuesday, April 27, 2010
Substance in Wine and Grapes Protects Against Endothelial Dysfunction.
CiteULike: Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.: "Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2."
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Monday, April 26, 2010
Proprionic Acid May Be Associated With IBS
"Propionic acid in rodents produces reversible behavior (e.g. hyperactivity, dystonia, social impairment, perseveration) and brain (e.g. innate neuroinflammation, glutathione depletion) changes reminiscent of autism.[3]"Propionic acid - Wikipedia, the free encyclopedia:
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GSK-3b - Regulator of Intestinal Inflammation
Well gee, have I not been saying this for months now???? GSK-3b also promotes neuroinflammation and may be responsible for brain inflammatory responses by intestinal inflammation. "Since this protein can inhibit neuroprotective antioxidant system -- this is probably highly likely." HEIRS_Health
Read more: HEIRS Blog Tags: GSK-3b
*****HEIRS Library Tag: GSK-3b
Glycogen synthase kinase 3-[beta]: A master regulator of toll-like receptor-mediated chronic intestinal inflammation
A disturbed regulation of Toll-like receptor (TLR) signal transduction resulting in the exclusive activation of proinflammatory signaling pathways may be critical for the perpetuation of established chronic colitis. Glycogen synthase kinase 3-[beta] (GSK3-[beta]) was recently identified as an important regulator of TLR signaling mediating excessive inflammatory responses.
Read more: HEIRS Blog Tags: GSK-3b
*****HEIRS Library Tag: GSK-3b
Glycogen synthase kinase 3-[beta]: A master regulator of toll-like receptor-mediated chronic intestinal inflammation
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Connections: Hearing Loss and Inflammatory Bowel Disease
CiteULike: Sensorineural Hearing Loss in Pediatric Patients with Inflammatory Bowel Disease: "Sensorineural Hearing Loss in Pediatric Patients with Inflammatory Bowel Disease"
Posted by
HEIRS Health & Home
at
7:57 AM
Labels:
autoimmune disease,
hearing loss,
IBD,
inflammatory bowel disease
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Chronic Elevated Ammonia Contributes to Neuroinflammation, Cognitive and Motor Dysfunction.
CiteULike: Hyperammonemia Induces Neuroinflammation that Contributes to Cognitive Impairment in Rats with Hepatic Encephalopathy.: "Chronic moderate hyperammonemia or BDL activated the microglia, especially in cerebellum; increased iNOS, IL-1beta, and prostaglandin E2 levels; and impaired cognitive and motor function, compared with controls"
Chronic hyperammonemia alters the circadian rhythm... [J Neurosci Res. 2010] - PubMed result
Chronic hyperammonemia alters the circadian rhythm... [J Neurosci Res. 2010] - PubMed result: "Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats."
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Sunday, April 25, 2010
Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase
Posted by
HEIRS Health & Home
at
4:55 PM
Labels:
cocaine,
dermatology,
drug abuse,
oxidative stress,
pharmacology,
skin damage
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Environmental factors maybe key in autism boom since 1988 says EPA
Environmental factors maybe key in autism boom since 1988 says EPA: "Environmental factors maybe key in autism boom since 1988 says EPA"
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Saturday, April 24, 2010
Anti-diabetic Drug May Ameliorate Inflammatory Effects on Kidney Tubules
Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3{beta}, Snail1, and {beta}-catenin in renal proximal tubule cells -- Lee and Han 298 (5): F1263 -- AJP - Renal Physiology: "HG induces EMT through ROS, PI3K/Akt, GSK-3β, Snail, and β-catenin. Subsequently, HG-induced EMT may result in SGLT dysfunction that is restored by the PPAR agonist troglitazone in primary cultured PTCs"
Posted by
HEIRS Health & Home
at
9:46 AM
Labels:
b-catenin,
glucose,
GSK-3B,
kidneys,
renal nephropathy,
renal tubules,
troglitazone
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Researchers Explain How Trauma Leads to Inflammatory Response - Beth Israel Deaconess Medical Center
Researchers Explain How Trauma Leads to Inflammatory Response - Beth Israel Deaconess Medical Center: "Findings show that mitochondria may be at the root of dangerous complications stemming from traumatic injury"
Posted by
HEIRS Health & Home
at
9:38 AM
Labels:
inflammatory response,
mitchondria,
traumatic injury
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Vitiligo Tied to Immune System Dysfunction - Skin Diseases, Conditions, Symptoms, and Procedures on MedicineNet.com
Vitiligo Tied to Immune System Dysfunction - Skin Diseases, Conditions, Symptoms, and Procedures on MedicineNet.com: "Scientists have discovered several genes linked to vitiligo that confirm the skin condition is, indeed, an autoimmune disorder."
Posted by
HEIRS Health & Home
at
9:34 AM
Labels:
dermatology,
immune dysfunction,
skin diseases,
vitiligo
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Friday, April 23, 2010
Thursday, April 22, 2010
Fatal ammonia toxicity in an adult due to an undiagnosed urea cycle defect: under-recognition of ornithine transcarbamylase deficiency.
CiteULike: Fatal ammonia toxicity in an adult due to an undiagnosed urea cycle defect: under-recognition of ornithine transcarbamylase deficiency.: "Thurlow, V. R., Asafu-Adjaye, M., Agalou, S., and Rahman, Y. (2010). Fatal ammonia toxicity in an adult due to an undiagnosed urea cycle defect: under-recognition of ornithine transcarbamylase deficiency. Annals of clinical biochemistry."
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Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival — Cardiovasc Res
Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival — Cardiovasc Res: "Nrf2-HO-1 signaling cascade as a crucial modulator of vascular cell survival during periods of nitrosative stress."
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Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha -induced hypertension in pregnant rats
CiteULike: Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha -induced hypertension in pregnant rats: "Davis, J. R., Giardina, J. B., Green, G. M., Alexander, B. T., Granger, J. P., and Khalil, R. A. (2002). Reduced endothelial no-cgmp vascular relaxation pathway during tnf-alpha -induced hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol, 282(2):R390-399."
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Wednesday, April 21, 2010
Natural taurine promotes apoptosis of human hepatic stellate cells in proteomics analysis.
CiteULike: Natural taurine promotes apoptosis of human hepatic stellate cells in proteomics analysis.: "Deng, X., Liang, J., Lin, Z.-X. X., Wu, F.-S. S., Zhang, Y.-P. P., and Zhang, Z.-W. W. (2010). Natural taurine promotes apoptosis of human hepatic stellate cells in proteomics analysis. World journal of gastroenterology : WJG, 16(15):1916-1923."
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Monday, April 19, 2010
Reducation of Pathogenic Activation with Mechanisms That Influence Tregs Production
CiteULike: Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation: "O'Mahony, C., Scully, P., O'Mahony, D., Murphy, S., O'Brien, F., Lyons, A., Sherlock, G., MacSharry, J., Kiely, B., Shanahan, F., and O'Mahony, L. (2008). Commensal-induced regulatory t cells mediate protection against pathogen-stimulated nf-κb activation. PLoS Pathog, 4(8):e1000112+."
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Sunday, April 18, 2010
Study Suggest Pain Involvement in Alterations in NO-cGMP Pathway
Nguelefack, T. B., Dutra, R. C., Paszcuk, A. F., Andrade, E. L., Tapondjou, L. A., and Calixto, J. B. (2010). Antinociceptive activities of the methanol extract of the bulbs of dioscorea bulbifera l. var sativa in mice is dependent of no-cgmp-atp-sensitive-k(+) channel activation. Journal of ethnopharmacology, 128(3):567-574.
http://www.citeulike.org/user/HEIRS/article/6664177
HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?
http://www.citeulike.org/user/HEIRS/article/6664177
HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?
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Skeletal Muscle Target For Bacterial Metabolic Changes Seen in Diabetes and Obesity
"skeletal muscle is a target for circulating endotoxin and may provide critical insight into the link between a proinflammatory state and dysregulated metabolism as observed with obesity, type 2 diabetes, and metabolic syndrome."Toll-like receptor 4 modulates skeletal muscle sub... [Am J Physiol Endocrinol Metab. 2010] - PubMed result:
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Saturday, April 17, 2010
NO-cGMP and Mitochondrial Biogenesis -- Mediator of PGC-1a
As we have noted, hyperammonia may impair the NO-cGMP pathway. Nisoli explains, "nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance."Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., and Carruba, M. O. (2003). Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science (New York, N.Y.), 299(5608):896-899. http://www.citeulike.org/user/HEIRS/article/7030900
HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?
Posted by
HEIRS Health & Home
at
7:20 PM
Labels:
hyperammonemia,
mitochondrial biogenesis,
NO-cGMP,
PGC-1a
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Wnt/beta-Catenin Signaling Activates and Determines Hepatic Zonal Expression of Glutathione S-Transferases in Mouse Liver
CiteULike: Wnt/beta-Catenin Signaling Activates and Determines Hepatic Zonal Expression of Glutathione S-Transferases in Mouse Liver: "Giera, S., Braeuning, A., Kohle, C., Bursch, W., Metzger, U., Buchmann, A., and Schwarz, M. (2010). Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione s-transferases in mouse liver. Toxicol. Sci., 115(1):22-33."
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Friday, April 16, 2010
Thursday, April 15, 2010
Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis
CiteULike: Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis: "Shawcross, D. (2004). Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. Journal of Hepatology, 40(2):247-254."
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Hyperammonemia increases sensitivity to LPS.
CiteULike: Hyperammonemia increases sensitivity to LPS.: "Marini, J. C. and Broussard, S. R. (2006). Hyperammonemia increases sensitivity to lps. Molecular genetics and metabolism, 88(2):131-137."
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CiteULike: Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice.
CiteULike: Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice.: "Marini, J. C., Lee, B., and Garlick, P. J. (2006). Ornithine restores ureagenesis capacity and mitigates hyperammonemia in otc(spf-ash) mice. The Journal of nutrition, 136(7):1834-1838."
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Nrf2 Inhibits Liposaccharide-Induced-Il-6 in RAW Macrophage Cell Line
CiteULike: Nrf2 Inhibits Liposaccharide-Induced-Il-6 in RAW Macrophage Cell Line: "Rangasemy, T., Chauhan, A., Singh, A., Stewart, J., Frampton, M., Yamamoto, M., Biswal, S., and Georas, S. (2009). Nrf2 inhibits liposaccharide-induced-il-6 in raw macrophage cell line. American Journal of Respiratory Critical Care Medicine, 179(A4184)."
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Gram (+) Bacterial Component Strongly Enhances Inflammatory Response in Rheum Arthritis...
CiteULike: Lipoteichoic acid enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, PKCdelta and c-Src dependent pathways.: "Tang, C.-H. H., Hsu, C.-J. J., Yang, W.-H. H., and Fong, Y.-C. C. (2010). Lipoteichoic acid enhances il-6 production in human synovial fibroblasts via tlr2 receptor, pkcdelta and c-src dependent pathways. Biochemical pharmacology, 79(11):1648-1657."
Posted by
HEIRS Health & Home
at
9:54 AM
Labels:
arthritis,
bacterial sepsis,
gram positive bacteria,
Il-6,
rheumatoid arthritis,
TLR2
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Downregulation of the Ornithine Decarboxylase/polyamine System Inhibits Angiotensin-induced Hypertrophy of Cardiomyocytes Through the NO/cGMP-dependent Protein Kinase Type-I Pathway
CiteULike: Downregulation of the Ornithine Decarboxylase/polyamine System Inhibits Angiotensin-induced Hypertrophy of Cardiomyocytes Through the NO/cGMP-dependent Protein Kinase Type-I Pathway: "Lin, Y., Liu, J.-C., Zhang, X.-J., Li, G.-W., Wang, L.-N., Xi, Y.-H., Li, H.-Z., Zhao, Y.-J., and Xu, C.-Q. (2010). Downregulation of the ornithine decarboxylase/polyamine system inhibits angiotensin-induced hypertrophy of cardiomyocytes through the no/cgmp-dependent protein kinase type-i pathway. Cellular Physiology and Biochemistry, 25(4-5)."
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Downregulation of the Ornithine System, the Heart and NO-cGMP!
Hypertrophy of cardiomyocytes was induced by AngII, this caused an increase in putrescine, spermidine and total polyamine pool in association with a decreased level of NO. Expressions of eNOS and PKG-I were down-regulated, [Ca2+]i was increased, and expressions of c-Fos and c-Myc upregulated. DFMO reversed these changes induced by AngII.Lin, Y., Liu, J.-C., Zhang, X.-J., Li, G.-W., Wang, L.-N., Xi, Y.-H., Li, H.-Z., Zhao, Y.-J., and Xu, C.-Q. (2010). Downregulation of the ornithine decarboxylase/polyamine system inhibits angiotensin-induced hypertrophy of cardiomyocytes through the no/cgmp-dependent protein kinase type-i pathway. Cellular Physiology and Biochemistry, 25(4-5).
HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?
Wednesday, April 14, 2010
Lithium Chloride and NO-cGMP Pathway
Our findings demonstrated that nitric oxide-cyclic GMP pathway could be involved in the anticonvulsant properties of the lithium chloride. In addition, the role of constitutive NOS versus inducible NOS is prominent in this phenomenon.
Bahremand, A., Nasrabady, S. E., Ziai, P., Rahimian, R., Hedayat, T., Payandemehr, B., and Dehpour, A. R. (2010). Involvement of nitric oxide-cgmp pathway in the anticonvulsant effects of lithium chloride on ptz-induced seizure in mice. Epilepsy Research, pages 295-302.
http://www.citeulike.org/user/HEIRS/article/7020649
HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?
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Suppression of Inflammatory Mediators by Cruciferous Vegetable-Derived Indole-3-Carbinol and Phenylethyl Isothiocyanate in Lipopolysaccharide-Activated Macrophages
I3C and PEITC both found in leafy green vegetables possess antiinflammatory effects by inhibiting the productions of NO, TNF-, and IL-10 in LPS-stimulated macrophages. NO’s inhibitory effect on I3C, in addition to decreasing the expression of iNOS, may at least partly be through interfering with iNOS enzyme activity as well as direct NO clearance activity, whereas PEITC may act through its direct NO clearance activity but not interfere with iNOS enzyme activity.CiteULike: Suppression of Inflammatory Mediators by Cruciferous Vegetable-Derived Indole-3-Carbinol and Phenylethyl Isothiocyanate in Lipopolysaccharide-Activated Macrophages: "Tsai, J.-T., Liu, H.-C., and Chen, Y.-H. (2010). Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages. Mediators of Inflammation."
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CFS Differences to Serotonin Suggest Different Condition Than FM
Mary Ann Liebert, Inc. - Journal of Women's Health - 0(0):: "Sex Differences in Plasma Prolactin Response to Tryptophan in Chronic Fatigue Syndrome Patients With and Without Comorbid Fibromyalgia"
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Gene that changes the brain’s response to stress identified
You may recall I have written about the potential of the influence of this hormone on a number of illnesses....
HEIRS Research Tag: BDNF
Gene that changes the brain’s response to stress identified
HEIRS Research Tag: BDNF
Gene that changes the brain’s response to stress identified
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Gene Variant May Raise Risk of Macular Degeneration.
Gene Variant May Raise Risk of Common Eye Disease - Eye Disorders and Vision Problems Including Cataracts, Lasik Eye Surgery, Blindness, Glaucoma and Eye Allergy on MedicineNet.com: "Gene Variant May Raise Risk of Common Eye Disease"
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Tuesday, April 13, 2010
CD154-CD40 T-cell pathway hepatic ischemia/reperfusion injury,blockade depends on HO-1
CiteULike: CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection.: "Shen, X.-D. D., Ke, B., Zhai, Y., Amersi, F., Gao, F., Anselmo, D. M., Busuttil, R. W., and Kupiec-Weglinski, J. W. (2002). Cd154-cd40 t-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection. Transplantation, 74(3):315-319."
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Tumor Necrosis Factor alpha and CD40 Ligand Antagonize the Inhibitory Effects of Interleukin 10 on T-Cell Stimulatory Capacity of Dendritic Cells
CiteULike: Tumor Necrosis Factor alpha and CD40 Ligand Antagonize the Inhibitory Effects of Interleukin 10 on T-Cell Stimulatory Capacity of Dendritic Cells: "Brossart, P., Zobywalski, A., Grunebach, F., Behnke, L., Stuhler, G., Reichardt, V. L., Kanz, L., and Brugger, W. (2000). Tumor necrosis factor alpha and cd40 ligand antagonize the inhibitory effects of interleukin 10 on t-cell stimulatory capacity of dendritic cells. Cancer Res, 60(16):4485-4492."
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Immunosuppressive Effects of Vitamin D
Potent Inhibition of Dendritic Cell Differentiation and Maturation by Vitamin D Analogs: "Griffin, M. (2000). Potent inhibition of dendritic cell differentiation and maturation by vitamin d analogs. Biochemical and Biophysical Research Communications, 270(3):701-708."