Blockade of Interleukin-6 Signaling Suppresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Th17 Responses.

Blockade of Interleukin-6 Signaling Suppresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Th17 Responses.

Association of polymorphisms in the human IL-10 and IL-18 genes with rheumatoid arthritis.

Association of polymorphisms in the human IL-10 and IL-18 genes with rheumatoid arthritis.

Sulforaphane Protects Brains against Hypoxic-Ischemic Injury through Induction of Nrf2-Dependent Phase 2 Enzyme.

Sulforaphane Protects Brains against Hypoxic-Ischemic Injury through Induction of Nrf2-Dependent Phase 2 Enzyme.

2010 Update: Consequences of Hypothalamicâ€"Pituitary Dysfunction Following Traumatic Brain Injury in Children

2010 Update: Consequences of Hypothalamicâ€"Pituitary Dysfunction Following Traumatic Brain Injury in Children

Short and Long Ter Vitamin Effects of Smoking

CiteULike: Long- and Short-term Effects of Tobacco Smoking on Circulating Concentrations of B Vitamins: "Ulvik, A., Ebbing, M., Hustad, S., Midttun, O., Nygard, O., Vollset, S. E., Bonaa, K. H., Nordrehaug, J. E., Nilsen, D. W., Schirmer, H., and Ueland, P. M. (2010). Long- and short-term effects of tobacco smoking on circulating concentrations of b vitamins. Clin Chem, 56(5):755-763."

Functional changes induced by psychological stress are not enough to cause intestinal inflammation in Sprague–Dawley rats

Functional changes induced by psychological stress are not enough to cause intestinal inflammation in Sprague–Dawley rats

Epigenetics in human disease and prospects for epigenetic therapy.

Epigenetics in human disease and prospects for epigenetic therapy.

Bacterial infection promotes DNA hypermethylation.

Bacterial infection promotes DNA hypermethylation.

In Children With CKD, Race Linked to Hemoglobin Levels

In Children With CKD, Race Linked to Hemoglobin Levels

Vitamin E, diabetes drug may reverse fatty liver disease

Vitamin E, diabetes drug may reverse fatty liver disease

A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis

A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis

Iron content of ferritin modulates its uptake by intestinal epithelium: implications for co-transport of prions

Iron content of ferritin modulates its uptake by intestinal epithelium: implications for co-transport of prions

PGC-1a and Exercise and Impact on Muscle Function and Insulin Sensitivity

"modest (~25%) upregulation of PGC-1alpha, within physiologic limits, does improve mitochondrial biogenesis, fatty acid oxidation and insulin sensitivity in healthy and insulin resistant skeletal muscle."

PGC-1{alpha} REGULATION BY EXERCISE TRAINING AND AND ITS INFLUENCES ON MUSCLE FUNCTION AND INSULIN SENSITIVITY [Am J Physiol Endocrinol Metab. 2010] - PubMed result:

Norrin Mediates Neuroprotective Effects on Retinal Ganglion Cells via Activation of the Wnt/{beta}-Catenin Signaling Pathway and the Induction of Neuroprotective Growth Factors in Muller Cells

Norrin Mediates Neuroprotective Effects on Retinal Ganglion Cells via Activation of the Wnt/{beta}-Catenin Signaling Pathway and the Induction of Neuroprotective Growth Factors in Muller Cells

Dysregulation of Dopamine Transporters via Dopamine D2 Autoreceptors Triggers Anomalous Dopamine Efflux Associated with Attention-Deficit Hyperactivity Disorder

Dysregulation of Dopamine Transporters via Dopamine D2 Autoreceptors Triggers Anomalous Dopamine Efflux Associated with Attention-Deficit Hyperactivity Disorder

CNS Leptin Action Modulates Immune Response and Survival in Sepsis

CNS Leptin Action Modulates Immune Response and Survival in Sepsis

Canonical TGF-{beta} Signaling Is Required for the Balance of Excitatory/Inhibitory Transmission within the Hippocampus and Prepulse Inhibition of Acoustic Startle

Canonical TGF-{beta} Signaling Is Required for the Balance of Excitatory/Inhibitory Transmission within the Hippocampus and Prepulse Inhibition of Acoustic Startle

Low Vitamin D Levels Are Related To MS Brain Atrophy, Cognitive Function, Studies Show

Low Vitamin D Levels Are Related To MS Brain Atrophy, Cognitive Function, Studies Show

Blockade of Interleukin-6 Signaling Suppresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Th17 Responses.

Blockade of Interleukin-6 Signaling Suppresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Th17 Responses.

Twins Study Points to Environmental Cause for MS

Twins Study Points to Environmental Cause for MS

Scientists Discover Substance That Causes Pain

Scientists Discover Substance That Causes Pain: "a family of fatty acids called oxidized linoleic acid metabolites (OLAMs) play an important role in the biology of pain."

How to Eat Less: Don't Put Food on the Table

How to Eat Less: Don't Put Food on the Table

Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A

Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A

'Epigenetic' Concepts Offer New Approach To Degenerative Disease

'Epigenetic' Concepts Offer New Approach To Degenerative Disease: "'Epigenetic' Concepts Offer New Approach To Degenerative Disease"

Hyperammonemia - Wikipedia, the free encyclopedia

Hyperammonemia - Wikipedia, the free encyclopedia: "Hyperammonemia"

Methylmercury Induces Acute Oxidative Stress, Altering Nrf2 Protein Level in Primary Microglial Cells

Methylmercury Induces Acute Oxidative Stress, Altering Nrf2 Protein Level in Primary Microglial Cells

Insulin Resistance in Skeletal Muscle

Pathogenesis of Insulin Resistance in Skeletal Muscle

S. Michigan: 4/ 26, 10 - White Pigeon Post Investigating Possible Abduction

April 26, 2010 - White Pigeon Post Investigating Possible Abduction

Substance in Wine and Grapes Protects Against Endothelial Dysfunction.

CiteULike: Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.: "Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2."

Proprionic Acid May Be Associated With IBS

"Propionic acid in rodents produces reversible behavior (e.g. hyperactivity, dystonia, social impairment, perseveration) and brain (e.g. innate neuroinflammation, glutathione depletion) changes reminiscent of autism.[3]"Propionic acid - Wikipedia, the free encyclopedia:

Alternative Lyme Disease Doctors Are Still Wrong

Alternative Lyme Disease Doctors Are Still Wrong

R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase

R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase

GSK-3b - Regulator of Intestinal Inflammation

Well gee, have I not been saying this for months now???? GSK-3b also promotes neuroinflammation and may be responsible for brain inflammatory responses by intestinal inflammation. "Since this protein can inhibit neuroprotective antioxidant system -- this is probably highly likely." HEIRS_Health

A disturbed regulation of Toll-like receptor (TLR) signal transduction resulting in the exclusive activation of proinflammatory signaling pathways may be critical for the perpetuation of established chronic colitis. Glycogen synthase kinase 3-[beta] (GSK3-[beta]) was recently identified as an important regulator of TLR signaling mediating excessive inflammatory responses.

Read more: HEIRS Blog Tags: GSK-3b
*****HEIRS Library Tag: GSK-3b


Glycogen synthase kinase 3-[beta]: A master regulator of toll-like receptor-mediated chronic intestinal inflammation

Connections: Hearing Loss and Inflammatory Bowel Disease

CiteULike: Sensorineural Hearing Loss in Pediatric Patients with Inflammatory Bowel Disease: "Sensorineural Hearing Loss in Pediatric Patients with Inflammatory Bowel Disease"

Chronic Elevated Ammonia Contributes to Neuroinflammation, Cognitive and Motor Dysfunction.

CiteULike: Hyperammonemia Induces Neuroinflammation that Contributes to Cognitive Impairment in Rats with Hepatic Encephalopathy.: "Chronic moderate hyperammonemia or BDL activated the microglia, especially in cerebellum; increased iNOS, IL-1beta, and prostaglandin E2 levels; and impaired cognitive and motor function, compared with controls"

Chronic hyperammonemia alters the circadian rhythm... [J Neurosci Res. 2010] - PubMed result

Chronic hyperammonemia alters the circadian rhythm... [J Neurosci Res. 2010] - PubMed result: "Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats."

Drinking Green Tea May Protect Eyes

Drinking Green Tea May Protect Eyes

Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase

Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase

Environmental factors maybe key in autism boom since 1988 says EPA

Environmental factors maybe key in autism boom since 1988 says EPA: "Environmental factors maybe key in autism boom since 1988 says EPA"

Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection

Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection

Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection

Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection

LSD and Ecstasy being used to combat cancer anxiety and post-traumatic stress disorder

LSD and Ecstasy being used to combat cancer anxiety and post-traumatic stress disorder

New Directions in the Epidemiology of Uterine Fibroids

New Directions in the Epidemiology of Uterine Fibroids

Not Again! The Role of Blood–Brain Barrier Failure in Epileptogenesis: A Molecular Update

Not Again! The Role of Blood–Brain Barrier Failure in Epileptogenesis: A Molecular Update

Endocrine disruptor, dioxin (TCDD)-induced mitochondrial dysfunction and apoptosis in human trophoblast-like JAR cells

Endocrine disruptor, dioxin (TCDD)-induced mitochondrial dysfunction and apoptosis in human trophoblast-like JAR cells

Dysfunction of Glutathione S-Transferase Leads to Excess 4-Hydroxy-2-Nonenal and H2O2 and Impaired Cytokine Pattern in Cultured Keratinocytes and Blood of Vitiligo Patients

Dysfunction of Glutathione S-Transferase Leads to Excess 4-Hydroxy-2-Nonenal and H2O2 and Impaired Cytokine Pattern in Cultured Keratinocytes and Blood of Vitiligo Patients

Anti-diabetic Drug May Ameliorate Inflammatory Effects on Kidney Tubules

Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3{beta}, Snail1, and {beta}-catenin in renal proximal tubule cells -- Lee and Han 298 (5): F1263 -- AJP - Renal Physiology: "HG induces EMT through ROS, PI3K/Akt, GSK-3β, Snail, and β-catenin. Subsequently, HG-induced EMT may result in SGLT dysfunction that is restored by the PPAR agonist troglitazone in primary cultured PTCs"

Researchers Explain How Trauma Leads to Inflammatory Response - Beth Israel Deaconess Medical Center

Researchers Explain How Trauma Leads to Inflammatory Response - Beth Israel Deaconess Medical Center: "Findings show that mitochondria may be at the root of dangerous complications stemming from traumatic injury"

Auditory function and hearing loss in children and adults with Williams syndrome: Cochlear impairment in individuals with otherwise normal hearing

Auditory function and hearing loss in children and adults with Williams syndrome: Cochlear impairment in individuals with otherwise normal hearing

Vitiligo Tied to Immune System Dysfunction - Skin Diseases, Conditions, Symptoms, and Procedures on MedicineNet.com

Vitiligo Tied to Immune System Dysfunction - Skin Diseases, Conditions, Symptoms, and Procedures on MedicineNet.com: "Scientists have discovered several genes linked to vitiligo that confirm the skin condition is, indeed, an autoimmune disorder."

Cognitive functions changes among Egyptian sewage network workers

Cognitive functions changes among Egyptian sewage network workers

Assessing Hormone Receptor Activities of Pyrethroid Insecticides and Their Metabolites in Reporter Gene Assays

Assessing Hormone Receptor Activities of Pyrethroid Insecticides and Their Metabolites in Reporter Gene Assays

Striatal Dopamine Modulates Basal Ganglia Output and Regulates Social Context-Dependent Behavioral Variability through D1 Receptors

Striatal Dopamine Modulates Basal Ganglia Output and Regulates Social Context-Dependent Behavioral Variability through D1 Receptors

Study to Test If Mouth, Gut Bacteria Trigger RA

Study to Test If Mouth, Gut Bacteria Trigger RA

Maternal endotoxin exposure attenuates allergic airway disease in infant rats

Maternal endotoxin exposure attenuates allergic airway disease in infant rats

Fatal ammonia toxicity in an adult due to an undiagnosed urea cycle defect: under-recognition of ornithine transcarbamylase deficiency.

CiteULike: Fatal ammonia toxicity in an adult due to an undiagnosed urea cycle defect: under-recognition of ornithine transcarbamylase deficiency.: "Thurlow, V. R., Asafu-Adjaye, M., Agalou, S., and Rahman, Y. (2010). Fatal ammonia toxicity in an adult due to an undiagnosed urea cycle defect: under-recognition of ornithine transcarbamylase deficiency. Annals of clinical biochemistry."

Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival — Cardiovasc Res

Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival — Cardiovasc Res: "Nrf2-HO-1 signaling cascade as a crucial modulator of vascular cell survival during periods of nitrosative stress."

Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha -induced hypertension in pregnant rats

CiteULike: Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha -induced hypertension in pregnant rats: "Davis, J. R., Giardina, J. B., Green, G. M., Alexander, B. T., Granger, J. P., and Khalil, R. A. (2002). Reduced endothelial no-cgmp vascular relaxation pathway during tnf-alpha -induced hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol, 282(2):R390-399."

Inhibition of dynamin-2 confers endothelial barrier dysfunctions by attenuating nitric oxide production.

Inhibition of dynamin-2 confers endothelial barrier dysfunctions by attenuating nitric oxide production.

Natural taurine promotes apoptosis of human hepatic stellate cells in proteomics analysis.

CiteULike: Natural taurine promotes apoptosis of human hepatic stellate cells in proteomics analysis.: "Deng, X., Liang, J., Lin, Z.-X. X., Wu, F.-S. S., Zhang, Y.-P. P., and Zhang, Z.-W. W. (2010). Natural taurine promotes apoptosis of human hepatic stellate cells in proteomics analysis. World journal of gastroenterology : WJG, 16(15):1916-1923."

Reducation of Pathogenic Activation with Mechanisms That Influence Tregs Production

CiteULike: Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation: "O'Mahony, C., Scully, P., O'Mahony, D., Murphy, S., O'Brien, F., Lyons, A., Sherlock, G., MacSharry, J., Kiely, B., Shanahan, F., and O'Mahony, L. (2008). Commensal-induced regulatory t cells mediate protection against pathogen-stimulated nf-κb activation. PLoS Pathog, 4(8):e1000112+."

Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats

Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats

Acute Exposure to Ozone Exacerbates Acetaminophen-Induced Liver Injury in Mice

Acute Exposure to Ozone Exacerbates Acetaminophen-Induced Liver Injury in Mice

Hydrogen Sulfide Regulates Homocysteine-Mediated Glomerulosclerosis.

Hydrogen Sulfide Regulates Homocysteine-Mediated Glomerulosclerosis.

Party drug could ease trauma long term

Party drug could ease trauma long term

Study Suggest Pain Involvement in Alterations in NO-cGMP Pathway

Nguelefack, T. B., Dutra, R. C., Paszcuk, A. F., Andrade, E. L., Tapondjou, L. A., and Calixto, J. B. (2010). Antinociceptive activities of the methanol extract of the bulbs of dioscorea bulbifera l. var sativa in mice is dependent of no-cgmp-atp-sensitive-k(+) channel activation. Journal of ethnopharmacology, 128(3):567-574.
http://www.citeulike.org/user/HEIRS/article/6664177


HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?

Skeletal Muscle Target For Bacterial Metabolic Changes Seen in Diabetes and Obesity

"skeletal muscle is a target for circulating endotoxin and may provide critical insight into the link between a proinflammatory state and dysregulated metabolism as observed with obesity, type 2 diabetes, and metabolic syndrome."Toll-like receptor 4 modulates skeletal muscle sub... [Am J Physiol Endocrinol Metab. 2010] - PubMed result:

NO-cGMP and Mitochondrial Biogenesis -- Mediator of PGC-1a

As we have noted, hyperammonia may impair the NO-cGMP pathway. Nisoli explains, "nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance."

Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., and Carruba, M. O. (2003). Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science (New York, N.Y.), 299(5608):896-899. http://www.citeulike.org/user/HEIRS/article/7030900





HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

T cell homeostasis in centenarians: from the thymus to the periphery.

T cell homeostasis in centenarians: from the thymus to the periphery.

Polymorphisms of Interleukin 1 Gene IL1RN Are Associated With Tourette Syndrome

Polymorphisms of Interleukin 1 Gene IL1RN Are Associated With Tourette Syndrome

Decrease in Asymmetrical Dimethylarginine, an Endogenous Nitric Oxide Synthase Inhibitor, in Cerebrospinal Fluid during Elderly Aging and in Patients with Sporadic Form of Amyotrophic Lateral Sclerosis

Decrease in Asymmetrical Dimethylarginine, an Endogenous Nitric Oxide Synthase Inhibitor, in Cerebrospinal Fluid during Elderly Aging and in Patients with Sporadic Form of Amyotrophic Lateral Sclerosis

Wnt/beta-Catenin Signaling Activates and Determines Hepatic Zonal Expression of Glutathione S-Transferases in Mouse Liver

CiteULike: Wnt/beta-Catenin Signaling Activates and Determines Hepatic Zonal Expression of Glutathione S-Transferases in Mouse Liver: "Giera, S., Braeuning, A., Kohle, C., Bursch, W., Metzger, U., Buchmann, A., and Schwarz, M. (2010). Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione s-transferases in mouse liver. Toxicol. Sci., 115(1):22-33."

Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume

Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume

Icariin Protects against Brain Injury by Enhancing SIRT1-dependent PGC-1alpha Expression in Experimental Stroke.

Icariin Protects against Brain Injury by Enhancing SIRT1-dependent PGC-1alpha Expression in Experimental Stroke.

TGF-β1 gene variant linked to asthma risk

TGF-β1 gene variant linked to asthma risk

Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis

CiteULike: Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis: "Shawcross, D. (2004). Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. Journal of Hepatology, 40(2):247-254."

Hyperammonemia increases sensitivity to LPS.

CiteULike: Hyperammonemia increases sensitivity to LPS.: "Marini, J. C. and Broussard, S. R. (2006). Hyperammonemia increases sensitivity to lps. Molecular genetics and metabolism, 88(2):131-137."

CiteULike: Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice.

CiteULike: Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice.: "Marini, J. C., Lee, B., and Garlick, P. J. (2006). Ornithine restores ureagenesis capacity and mitigates hyperammonemia in otc(spf-ash) mice. The Journal of nutrition, 136(7):1834-1838."

Michigan: April 15, 2010 - New Rules for Commercial Passenger Vehicles, Enforcement begins in June

April 15, 2010 - New Rules for Commercial Passenger Vehicles, Enforcement begins in June

Nrf2 Inhibits Liposaccharide-Induced-Il-6 in RAW Macrophage Cell Line

CiteULike: Nrf2 Inhibits Liposaccharide-Induced-Il-6 in RAW Macrophage Cell Line: "Rangasemy, T., Chauhan, A., Singh, A., Stewart, J., Frampton, M., Yamamoto, M., Biswal, S., and Georas, S. (2009). Nrf2 inhibits liposaccharide-induced-il-6 in raw macrophage cell line. American Journal of Respiratory Critical Care Medicine, 179(A4184)."

Gram (+) Bacterial Component Strongly Enhances Inflammatory Response in Rheum Arthritis...

CiteULike: Lipoteichoic acid enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, PKCdelta and c-Src dependent pathways.: "Tang, C.-H. H., Hsu, C.-J. J., Yang, W.-H. H., and Fong, Y.-C. C. (2010). Lipoteichoic acid enhances il-6 production in human synovial fibroblasts via tlr2 receptor, pkcdelta and c-src dependent pathways. Biochemical pharmacology, 79(11):1648-1657."

Downregulation of the Ornithine Decarboxylase/polyamine System Inhibits Angiotensin-induced Hypertrophy of Cardiomyocytes Through the NO/cGMP-dependent Protein Kinase Type-I Pathway

CiteULike: Downregulation of the Ornithine Decarboxylase/polyamine System Inhibits Angiotensin-induced Hypertrophy of Cardiomyocytes Through the NO/cGMP-dependent Protein Kinase Type-I Pathway: "Lin, Y., Liu, J.-C., Zhang, X.-J., Li, G.-W., Wang, L.-N., Xi, Y.-H., Li, H.-Z., Zhao, Y.-J., and Xu, C.-Q. (2010). Downregulation of the ornithine decarboxylase/polyamine system inhibits angiotensin-induced hypertrophy of cardiomyocytes through the no/cgmp-dependent protein kinase type-i pathway. Cellular Physiology and Biochemistry, 25(4-5)."

Downregulation of the Ornithine System, the Heart and NO-cGMP!

Hypertrophy of cardiomyocytes was induced by AngII, this caused an increase in putrescine, spermidine and total polyamine pool in association with a decreased level of NO. Expressions of eNOS and PKG-I were down-regulated, [Ca2+]i was increased, and expressions of c-Fos and c-Myc upregulated. DFMO reversed these changes induced by AngII.

Lin, Y., Liu, J.-C., Zhang, X.-J., Li, G.-W., Wang, L.-N., Xi, Y.-H., Li, H.-Z., Zhao, Y.-J., and Xu, C.-Q. (2010). Downregulation of the ornithine decarboxylase/polyamine system inhibits angiotensin-induced hypertrophy of cardiomyocytes through the no/cgmp-dependent protein kinase type-i pathway. Cellular Physiology and Biochemistry, 25(4-5).





HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?

Lithium Chloride and NO-cGMP Pathway

Our findings demonstrated that nitric oxide-cyclic GMP pathway could be involved in the anticonvulsant properties of the lithium chloride. In addition, the role of constitutive NOS versus inducible NOS is prominent in this phenomenon.

Bahremand, A., Nasrabady, S. E., Ziai, P., Rahimian, R., Hedayat, T., Payandemehr, B., and Dehpour, A. R. (2010). Involvement of nitric oxide-cgmp pathway in the anticonvulsant effects of lithium chloride on ptz-induced seizure in mice. Epilepsy Research, pages 295-302.
http://www.citeulike.org/user/HEIRS/article/7020649


HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?

Suppression of Inflammatory Mediators by Cruciferous Vegetable-Derived Indole-3-Carbinol and Phenylethyl Isothiocyanate in Lipopolysaccharide-Activated Macrophages

I3C and PEITC both found in leafy green vegetables possess antiinflammatory effects by inhibiting the productions of NO, TNF-, and IL-10 in LPS-stimulated macrophages. NO’s inhibitory effect on I3C, in addition to decreasing the expression of iNOS, may at least partly be through interfering with iNOS enzyme activity as well as direct NO clearance activity, whereas PEITC may act through its direct NO clearance activity but not interfere with iNOS enzyme activity.

CiteULike: Suppression of Inflammatory Mediators by Cruciferous Vegetable-Derived Indole-3-Carbinol and Phenylethyl Isothiocyanate in Lipopolysaccharide-Activated Macrophages: "Tsai, J.-T., Liu, H.-C., and Chen, Y.-H. (2010). Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages. Mediators of Inflammation."

Suppression of gluconeogenesis by Metformin

Suppression of gluconeogenesis by Metformin

Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro.

Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro.

Antigen-Specific CD25-Foxp3-IFN-{gamma}highCD4+ T Cells Restrain the Development of Experimental Allergic Encephalomyelitis by Suppressing Th17.

Antigen-Specific CD25-Foxp3-IFN-{gamma}highCD4+ T Cells Restrain the Development of Experimental Allergic Encephalomyelitis by Suppressing Th17.

Antigen-Specific CD25-Foxp3-IFN-{gamma}highCD4+ T Cells Restrain the Development of Experimental Allergic Encephalomyelitis by Suppressing Th17.

Antigen-Specific CD25-Foxp3-IFN-{gamma}highCD4+ T Cells Restrain the Development of Experimental Allergic Encephalomyelitis by Suppressing Th17.

Role of Treg in immune regulation of allergic diseases

Role of Treg in immune regulation of allergic diseases

CFS Differences to Serotonin Suggest Different Condition Than FM

Mary Ann Liebert, Inc. - Journal of Women's Health - 0(0):: "Sex Differences in Plasma Prolactin Response to Tryptophan in Chronic Fatigue Syndrome Patients With and Without Comorbid Fibromyalgia"

OX40 is required for regulatory T cell-mediated control of colitis

OX40 is required for regulatory T cell-mediated control of colitis

Vitamin B12 deficiency in a 15-year old boy due to mutations in the intrinsic factor gene, GIF

Vitamin B12 deficiency in a 15-year old boy due to mutations in the intrinsic factor gene, GIF

Particulate Matter Induces IL-6 Translocation from the Lung to the Systemic Circulation.

Particulate Matter Induces IL-6 Translocation from the Lung to the Systemic Circulation.

Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons

Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons

Gene that changes the brain’s response to stress identified

You may recall I have written about the potential of the influence of this hormone on a number of illnesses....

HEIRS  Research Tag: BDNF


Gene that changes the brain’s response to stress identified

Guillain-Barré Syndrome Cases Low After 2009 H1N1 Vaccine

Guillain-Barré Syndrome Cases Low After 2009 H1N1 Vaccine

Public Health Week 2010 Celebrates Local Heroes

Public Health Week 2010 Celebrates Local Heroes

Gene Variant May Raise Risk of Macular Degeneration.

Gene Variant May Raise Risk of Common Eye Disease - Eye Disorders and Vision Problems Including Cataracts, Lasik Eye Surgery, Blindness, Glaucoma and Eye Allergy on MedicineNet.com: "Gene Variant May Raise Risk of Common Eye Disease"

Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice

Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice

CD154-CD40 T-cell pathway hepatic ischemia/reperfusion injury,blockade depends on HO-1

CiteULike: CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection.: "Shen, X.-D. D., Ke, B., Zhai, Y., Amersi, F., Gao, F., Anselmo, D. M., Busuttil, R. W., and Kupiec-Weglinski, J. W. (2002). Cd154-cd40 t-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection. Transplantation, 74(3):315-319."

Tumor Necrosis Factor alpha and CD40 Ligand Antagonize the Inhibitory Effects of Interleukin 10 on T-Cell Stimulatory Capacity of Dendritic Cells

CiteULike: Tumor Necrosis Factor alpha and CD40 Ligand Antagonize the Inhibitory Effects of Interleukin 10 on T-Cell Stimulatory Capacity of Dendritic Cells: "Brossart, P., Zobywalski, A., Grunebach, F., Behnke, L., Stuhler, G., Reichardt, V. L., Kanz, L., and Brugger, W. (2000). Tumor necrosis factor alpha and cd40 ligand antagonize the inhibitory effects of interleukin 10 on t-cell stimulatory capacity of dendritic cells. Cancer Res, 60(16):4485-4492."

Immunosuppressive Effects of Vitamin D

Potent Inhibition of Dendritic Cell Differentiation and Maturation by Vitamin D Analogs: "Griffin, M. (2000). Potent inhibition of dendritic cell differentiation and maturation by vitamin d analogs. Biochemical and Biophysical Research Communications, 270(3):701-708."