Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes.

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes.: "Glucose at high concentrations induced ROS production in both primary neonatal and adult cardiomyocytes from the Nrf2 wild type (WT) mouse heart, whereas, in Nrf2 knockout (KO) cells, ROS was significantly higher under basal conditions and high glucose markedly further increased ROS production in concentration and time-dependent manners. Concomitantly, high glucose induced significantly higher levels of apoptosis at lower concentrations and in shorter time in Nrf2 KO cells than in WT cells."