Anti-diabetic Drug May Ameliorate Inflammatory Effects on Kidney Tubules

Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3{beta}, Snail1, and {beta}-catenin in renal proximal tubule cells -- Lee and Han 298 (5): F1263 -- AJP - Renal Physiology: "HG induces EMT through ROS, PI3K/Akt, GSK-3β, Snail, and β-catenin. Subsequently, HG-induced EMT may result in SGLT dysfunction that is restored by the PPAR agonist troglitazone in primary cultured PTCs"