Researchers uncover novel genetic pathway responsible for triggering vascular growth

Researchers uncover novel genetic pathway responsible for triggering vascular growth




Most solid cancers can't grow beyond a limited size without an adequate blood supply and supporting vascular network. Because of this, cancer researchers have sought to understand how a tumor's vascular network develops—and, more importantly, how to prevent it from developing: If the vascular network never develops, the theory goes, the tumor cannot grow.

Protein Important for Mitochondrial Biogenesis Cooperates With HO-1 To Increase Stress Resistance In Endothelial Cells

ConclusionWe have identified an important relationship between PPARdelta, PGC1alpha, and haem oxygenase-1, demonstrating that haem oxygenase-1 induction plays an important role in cytoprotective actions of PPARdelta ligands in vascular endothelium. In light of the protective effects of haem oxygenase-1 against atherogenesis, we suggest that PPARdelta represents a potentially important therapeutic target in the vasculature.

CiteULike: PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress: "Ali, F., Ali, N. S., Bauer, A., Boyle, J. J., Hamdulay, S. S., Haskard, D. O., Randi, A. M., and Mason, J. C. (2010). Ppardelta and pgc1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress. Cardiovasc Res, 85(4):701-710."