GSK-3b - Regulator of Intestinal Inflammation

Well gee, have I not been saying this for months now???? GSK-3b also promotes neuroinflammation and may be responsible for brain inflammatory responses by intestinal inflammation. "Since this protein can inhibit neuroprotective antioxidant system -- this is probably highly likely." HEIRS_Health

A disturbed regulation of Toll-like receptor (TLR) signal transduction resulting in the exclusive activation of proinflammatory signaling pathways may be critical for the perpetuation of established chronic colitis. Glycogen synthase kinase 3-[beta] (GSK3-[beta]) was recently identified as an important regulator of TLR signaling mediating excessive inflammatory responses.

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Glycogen synthase kinase 3-[beta]: A master regulator of toll-like receptor-mediated chronic intestinal inflammation

Il-1b Alters Neurotransmitter Responses- Implications for Intestinal Inflammation!

Title: Prolonged il-1β exposure alters neurotransmitter and electrically induced ca²⁺ responses in the myenteric plexus.

Summary: This study suggests that "IL-1b could be implicated in the motility disturbances observed during gastrointestinal inflammation."


Kindt, den Berghe, Boesmans, Roosen, and Tack (2009). Prolonged il-1β exposure alters neurotransmitter and electrically induced ca²⁺ responses in the myenteric plexus. Neurogastroenterology & Motility, 9999(9999).