Airborne fine particulate matter induced pulmonary inflammation as well as oxidative stress in neonate rats.

"Study demonstrated acute exposure to fine PM induced airway inflammation as well as increased oxidative stress in addition to its direct toxic effect on airway epithelium cells."

Read more: CiteULike: Airborne fine particulate matter induced pulmonary inflammation as well as oxidative stress in neonate rats.:

Air pollution and circulating biomarkers of oxidative stress

"Chemical components of air pollutant exposures that induce oxidative stress and subsequent inflammation may be partly responsible for associations of cardiovascular morbidity and mortality with airborne particulate matter and combustion-related pollutant gasses"

Read more: CiteULike: Air pollution and circulating biomarkers of oxidative stress:

Melatonin protects against endosulfan-induced oxidative tissue damage in rats.

"Omurtag, G. Z., Tozan, A., Sehirli, A. O. O., and Sener, G. (2008). Melatonin protects against endosulfan-induced oxidative tissue damage in rats. Journal of pineal research, 44(4):432-438."

Read more: CiteULike: Melatonin protects against endosulfan-induced oxidative tissue damage in rats.:

Cell signaling mediated by nitrated cyclic guanine nucleotide.

"8-Nitro-cGMP activated the Nrf2 signaling pathway by triggering dissociation of Keap1, via S-guanylation of its highly nucleophilic cysteine sulfhydryls. We also determined that S-guanylation of Keap1 was involved in cytoprotective actions of NO and 8-nitro-cGMP by inducing oxidative stress response genes such as heme oxygenase-1"


Read more: CiteULike: Cell signaling mediated by nitrated cyclic guanine nucleotide.:

Metals, oxidative stress and neurodegenerative disorders.

"Jomova, K., Vondrakova, D., Lawson, M., and Valko, M. (2010). Metals, oxidative stress and neurodegenerative disorders. Molecular and cellular biochemistry."

Abstract link: CiteULike: Metals, oxidative stress and neurodegenerative disorders.:

Antioxidant System Deficiency Increases Allergic Immune Response~!

Background: Nrf2 expression can be influenced by a number of factors including diet and age and may influence or be influenced by the expression of other proteins.

Rangasamy demonstrates that immune reactions from ragweed are more severe in Nrf2-deficiency. The author's findings suggest that "defect in Nrf2 mediated signaling mechanisms alters the response of DC to a common environmental allergen, which may contribute to the susceptibility to allergic diseases." Importantly, one must also note that other studies have suggest endotoxin reduces the threshold for allergic reactions and EGCG, the compound found in green tea, has a suppressive influence on histamine producing cells. More and more studies are providing evidence that EGCG acts through the Nrf2 antioxidant system and therefore should warrant further study as therapeutic for allergic-type reactions.


Rangasamy, T., Williams, M. A., Bauer, S., Trush, M. A., Emo, J., Georas, S. N., and Biswal, S. (2009). Nrf2 inhibits the maturation of murine dendritic cells by ragweed extract. American Journal of Respiratory Cell and Molecular Biology.
http://www.citeulike.org/user/HEIRS/article/7652681
Melgarejo, E., Medina, M. A. A., Sánchez-Jiménez, F., and Urdiales, J. L. L. (2010). Targeting of histamine producing cells by egcg: a green dart against inflammation? Journal of physiology and biochemistry, 66(3):265-270.
http://www.citeulike.org/user/HEIRS/article/7652686

PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload

"This data indicates that PGC-1α plays an important role in regulating expression of myocardial mitochondrial antioxidants SOD2 and Trx2 and in protecting hearts against TAC-induced myocardial oxidative stress, hypertrophy, and dysfunction."

"Lu, Z., Xu, X., Hu, X., Fassett, J., Zhu, G., Tao, Y., Li, J., Huang, Y., Zhang, P., Zhao, B., and Chen, Y. (2010). Pgc-1α regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxidants and Redox Signaling."

Read more: CiteULike: PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload:

Oxidative and nitrosative stress contribute to lupus disease activity

University of Texas Medical Branch researchers have uncovered an association between free radical-mediated reactions and the severity and progression of system lupus erythematosus (SLE). Higher levels of oxidative and nitrosative stress markers were found in SLE patients with greater disease activity suggesting a causal relationship. Full findings of the study are available in the July issue of Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.

Oxidative and nitrosative stress contribute to lupus disease activity:

Clinical trial shows reduced oxidative stress of preterm neonates w/ Omega 3

"Oxidative stress was significantly reduced in those neonates fed with ω-3 fatty acids, whereas no effect was observed in the neonates fed with standard lipids. Intervention had no effect on infants’ growth and clinical outcome."

European Journal of Clinical Nutrition - Abstract of article: A double-blind, randomized clinical trial of the effect of [omega]-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition:




Ultra EPA - Fish Oil (90 softgels)

Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain

Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain

Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the Nrf2-Keap1 defense pathway.

"We hypothesize that diminished Nrf2/ARE activity contributes to increased oxidative stress and mitochondrial dysfunction in the vasculature leading to endothelial dysfunction, insulin resistance and abnormal angiogenesis observed in diabetes"

CiteULike: Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the Nrf2-Keap1 defense pathway.:

Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase

Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase

Antioxidant Acitvator of Nrf2 Suppresses Angiotensin and Oxidative Stress in the Heart.

Angiotensin is a strong activator of oxidative stress. A new study reports that a chemical compound that activates the Nrf2 system suppresses oxidative stress via angiotensin.

Ichikawa, T., Li, J., Meyer, C. J., Janicki, J. S., Hannink, M., and Cui, T. (2009). Dihydro-cddo-trifluoroethyl amide (dh404), a novel nrf2 activator, suppresses oxidative stress in cardiomyocytes. PloS one, 4(12). http://www.citeulike.org/user/HEIRS/article/6463013

Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats

Obesity and hypertension are the two major risk factors that contribute to the progression of end-stage renal disease. To examine whether hypertension further exacerbates oxidative stress and vascular dysfunction and inflammation in obese rats, four groups of male Sprague–Dawley rats were fed either a normal (7% fat) or high-fat (36% fat) diet for 6 weeks and osmotic pumps were implanted to deliver ANG (angiotensin II) or vehicle for an additional 4 weeks.

LINK

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

Title: Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria.

Summary: "H2S enhances GSH by enhancing cystine/cysteine transporters and redistributes GSH to mitochondria. H2S produced in mitochondria also may directly suppress oxidative stress. It provides a new mechanism of neuroprotection from oxidative stress by H2S."

Kimura, Y., Goto, Y.-I., and Kimura, H. (2009). Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria. Antioxidants & Redox Signaling, pages 091026040507095+. http://www.citeulike.org/user/HEIRS/article/6015103

Genetic dissection of systemic autoimmune disease in nrf2 deficient mice.

Title: Genetic dissection of systemic autoimmune disease in nrf2 deficient mice.

Summary: "SLE occurs with an prevalence as high as 1 in 2,500 people but predominantly affects women (35). SLE is especially prevalent in women during their childbearing years (9:1 female to male ratio) and during pregnancy, suggesting a role of female hormones in development of the disease. Most mouse models of SLE also exhibit an increased susceptibility of females to the disease. The sex-specific decreases in glutathione S-transferase -1 and -2 and µ-1, -2, and -3 have been shown previously in the livers of nrf2 knockout mice (10) and are in agreement with our study (Table 3). The findings from this data and other reports strongly suggest that a deficiency in detoxification and increased oxidative stress can result in the development of a systemic autoimmune disease."

Li, J., Stein, T. D., and Johnson, J. A. (2004). Genetic dissection of systemic autoimmune disease in nrf2 deficient mice. Physiological Genomics, pages 1-57.  http://www.citeulike.org/user/HEIRS/article/6012655

Phytochemicals Help To Reduce Oxidative Stress, Inflammation,Obesity and Diabetes

"The cheeseburger and French fries might look tempting, but eating a serving of broccoli or leafy greens first could help people battle metabolic processes that lead to obesity and heart disease, a new University of Florida study shows." Click here.

Oxidative Stress from Low Dose Ozone Causes Neurodegeneration in the Brain

Oxidative Stress Caused by Ozone Exposure Induces Loss of Brain Repair in The Hippocampus of Adult Rats

Summary: "oxidative stress caused by low doses of ozone causes dysregulation of inflammatory processes, progressive neurodegeneration, chronic loss of brain repair in the hippocampus causing impaired memory, and brain plasticity changes in the rat analogous to those seen in Alzheimer's disease."

Rivas-Arancibia, S., Guevara-Guzman, R., Lopez-Vidal, Y., Rodriguez-Martinez, E., Gomes, M. Z., Angoa-Perez, M., and Raisman-Vozari, R. (2009). Oxidative stress caused by ozone exposure induces loss of brain repair in the hippocampus of adult rats. Toxicol. Sci., pages kfp252+.
Link

Note: ozone is ozone -- does not matter if it produced mechanically or from chemical components in air.

Oxidative Stress, T3 and Other Markers May Be Beneficial to Monitor Liver Disease

Title: Oxidative stress and thyroid hormones in patients with liver diseases

Summary: The measurement of the total T(3), NO, MDA, GSH reduced and GSHPx as biomarkers for liver diseases might be a beneficial tool, helping in monitoring the state of liver disease patients.

Citation: Moustafa, A. H. H., Ali, E. M., Mohamed, T. M., and Abdou, H. I. (2009). Oxidative stress and thyroid hormones in patients with liver diseases. European journal of internal medicine, 20(7):703-708. http://www.citeulike.org/user/HEIRS/article/5787830

HIF-1 May Provide Protection in Parkinson's and Metal-Induced Oxidative Stress Disorders

Title: Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.

Summary: "protection against MPTP neurotoxicity may be mediated by alterations in iron homeostasis and defense against oxidative stress and mitochondrial dysfunction brought about by cellular HIF-1α induction. This study provides novel data extending the possible therapeutic utility of HIF induction to a Parkinson disease model of neurodegeneration, which may prove beneficial not only in this disorder itself but also in other diseases associated with metal-induced oxidative stress."


Lee, D. W., Rajagopalan, S., Siddiq, A., Gwiazda, R., Yang, L., Beal, M. F., Ratan, R. R., and Andersen, J. K. (2009). Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Journal of Biological Chemistry, 284(42):29065-29076.