A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential.

Go, Y.-M. M., Park, H., Koval, M., Orr, M., Reed, M., Liang, Y., Smith, D., Pohl, J., and Jones, D. P. (2009). A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential. Free radical biology & medicine. http://www.citeulike.org/user/HEIRS/article/6076359

The specificity of neuroprotection by antioxidants.

In this model, extracellularly added glutamate inhibits cystine uptake through the cystine/glutamate antiporter, resulting in the depletion of intracellular cysteine and GSH. When the cellular GSH level drops below 20% of the control, an explosive generation of ROS occurs that is required for the subsequent cell death. (Pg. 13)

Liu, Y. and Schubert, D. (2009). The specificity of neuroprotection by antioxidants. Journal of Biomedical Science, 16(1):98+. http://www.citeulike.org/user/HEIRS/article/6079766

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

Title: Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria.

Summary: "H2S enhances GSH by enhancing cystine/cysteine transporters and redistributes GSH to mitochondria. H2S produced in mitochondria also may directly suppress oxidative stress. It provides a new mechanism of neuroprotection from oxidative stress by H2S."

Kimura, Y., Goto, Y.-I., and Kimura, H. (2009). Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria. Antioxidants & Redox Signaling, pages 091026040507095+. http://www.citeulike.org/user/HEIRS/article/6015103