The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.

"Transcription factor Nrf2 regulates genes encoding drug-metabolising enzymes and drug transporters, as well as enzymes involved in the glutathione, thioredoxin and peroxiredoxin antioxidant pathways......."

Read more: CiteULike: The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics

Thioredoxin-interacting protein (txnip) is a feedback regulator of s-nitrosylation

Summary: Researh findings reveal that denitrosylation of proteins is dynamically regulated, establish a physiological role for thioredoxin in protection from nitrosative stress, and suggest new approaches to manipulate cellular -nitrosylation.





Forrester, M. T., Seth, D., Hausladen, A., Eyler, C. E., Foster, M. W., Matsumoto, A., Benhar, M., Marshall, H. E., and Stamler, J. S. (2009). Thioredoxin-interacting protein (txnip) is a feedback regulator of s-nitrosylation. Journal of Biological Chemistry, 284(52):36160-36166. http://www.citeulike.org/user/HEIRS/article/6414079

A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential.

Go, Y.-M. M., Park, H., Koval, M., Orr, M., Reed, M., Liang, Y., Smith, D., Pohl, J., and Jones, D. P. (2009). A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential. Free radical biology & medicine. http://www.citeulike.org/user/HEIRS/article/6076359