The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.

"Transcription factor Nrf2 regulates genes encoding drug-metabolising enzymes and drug transporters, as well as enzymes involved in the glutathione, thioredoxin and peroxiredoxin antioxidant pathways......."

Read more: CiteULike: The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling.

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling.: "URL: Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling.

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Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

Summary: Prxs function as redox sensors that transmit signals as part of the cellular response to oxidative stress. In mammals, Prx 3 and Prx 5 are targeted to the mitochondrial matrix. Mitochondria are a major source of hydrogen peroxide, and this oxidant is implicated in the damage associated with aging and a number of pathologies

Cox, A. G., Winterbourn, C. C., and Hampton, M. B. (2010). Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. The Biochemical journal, 425(2):313-325. http://www.citeulike.org/user/HEIRS/article/6440040





Mitochondria and Free Radicals in Neurodegenerative Diseases

The Effect of Disruption of Genes for Peroxiredoxin-2, Glutathione Peroxidase-1 and Catalase on Erythrocyte Oxidative Metabolism.

The Effect of Disruption of Genes for Peroxiredoxin-2, Glutathione Peroxidase-1 and Catalase on Erythrocyte Oxidative Metabolism.: "URL: The Effect of Disruption of Genes for Peroxiredoxin-2, Glutathione Peroxidase-1 and Catalase on Erythrocyte Oxidative Metabolism.

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