Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

Summary: Prxs function as redox sensors that transmit signals as part of the cellular response to oxidative stress. In mammals, Prx 3 and Prx 5 are targeted to the mitochondrial matrix. Mitochondria are a major source of hydrogen peroxide, and this oxidant is implicated in the damage associated with aging and a number of pathologies

Cox, A. G., Winterbourn, C. C., and Hampton, M. B. (2010). Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. The Biochemical journal, 425(2):313-325. http://www.citeulike.org/user/HEIRS/article/6440040





Mitochondria and Free Radicals in Neurodegenerative Diseases