Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle pgc-1alpha/mitofusin-2 regulatory pathway in response to physical activity.

Summary: The results of this experiment demonstrates there exists "alterations in the regulatory pathway that controls PGC-1alpha expression, and induction of Mfn2 in muscle from patients with early onset type 2 diabetes. Patients with early-onset type 2 diabetes display abnormalities in the exercise-dependent pathway that regulates the expression of PGC-1alpha and Mfn2."




Hernández-Alvarez, M. I. I., Thabit, H., Burns, N., Shah, S., Brema, I., Hatunic, M., Finucane, F., Liesa, M., Chiellini, C., Naon, D., Zorzano, A., and Nolan, J. J. (2009). Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle pgc-1alpha/mitofusin-2 regulatory pathway in response to physical activity. Diabetes care.  http://www.citeulike.org/user/HEIRS/article/6440056


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