The specificity of neuroprotection by antioxidants.

In this model, extracellularly added glutamate inhibits cystine uptake through the cystine/glutamate antiporter, resulting in the depletion of intracellular cysteine and GSH. When the cellular GSH level drops below 20% of the control, an explosive generation of ROS occurs that is required for the subsequent cell death. (Pg. 13)

Liu, Y. and Schubert, D. (2009). The specificity of neuroprotection by antioxidants. Journal of Biomedical Science, 16(1):98+. http://www.citeulike.org/user/HEIRS/article/6079766