The calcium (Ca2+)-calmodulin (CaM)-CaM kinase (K)IIalpha signal passage plays an important role in the plasticity of central nervous, learning and memory, mind and behavior and other types of cognitive activities. The amygdala is known to play an important role in fear, rage and emotional memory. In this study, it was found that CAM levels increase while CAMKII-alpha decrease from prolonged stress. Therefore, dysfunction of CAM/CAMKII-alpha may play a role in PTSD.For further reading: Library Tag: CAMKII
Xiao, B., Han, F., and Shi, Y.-X. X. (2009). Dysfunction of ca2+/cam kinase iialpha cascades in the amygdala in post-traumatic stress disorder. International journal of molecular medicine, 24(6):795-799. http://www.citeulike.org/user/HEIRS/article/6081031
No comments:
Post a Comment