Background: Nrf2 expression can be influenced by a number of factors including diet and age and may influence or be influenced by the expression of other proteins.
Rangasamy demonstrates that immune reactions from ragweed are more severe in Nrf2-deficiency. The author's findings suggest that "defect in Nrf2 mediated signaling mechanisms alters the response of DC to a common environmental allergen, which may contribute to the susceptibility to allergic diseases." Importantly, one must also note that other studies have suggest endotoxin reduces the threshold for allergic reactions and EGCG, the compound found in green tea, has a suppressive influence on histamine producing cells. More and more studies are providing evidence that EGCG acts through the Nrf2 antioxidant system and therefore should warrant further study as therapeutic for allergic-type reactions.
Rangasamy, T., Williams, M. A., Bauer, S., Trush, M. A., Emo, J., Georas, S. N., and Biswal, S. (2009). Nrf2 inhibits the maturation of murine dendritic cells by ragweed extract. American Journal of Respiratory Cell and Molecular Biology.
http://www.citeulike.org/user/HEIRS/article/7652681
Melgarejo, E., Medina, M. A. A., Sánchez-Jiménez, F., and Urdiales, J. L. L. (2010). Targeting of histamine producing cells by egcg: a green dart against inflammation? Journal of physiology and biochemistry, 66(3):265-270.
http://www.citeulike.org/user/HEIRS/article/7652686
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