Antioxidant Acitvator of Nrf2 Suppresses Angiotensin and Oxidative Stress in the Heart.

Angiotensin is a strong activator of oxidative stress. A new study reports that a chemical compound that activates the Nrf2 system suppresses oxidative stress via angiotensin.

Ichikawa, T., Li, J., Meyer, C. J., Janicki, J. S., Hannink, M., and Cui, T. (2009). Dihydro-cddo-trifluoroethyl amide (dh404), a novel nrf2 activator, suppresses oxidative stress in cardiomyocytes. PloS one, 4(12). http://www.citeulike.org/user/HEIRS/article/6463013

Pgc-1alpha serine570 phosphorylation and gcn5-mediated acetylation by angiotensin ii drive catalase downregulation and vascular hypertrophy.

Summary:Angiotensin is a hormone that contributes to conditions such as aging, insulin resistance and cardiovascular disease.  PGC-1a is a negative regulator of vascular hypertrophy and H2O2 elevations by upregulating catalase and reducing ROS.

Xiong, S., Salazar, G., San Martin, A., Ahmad, M., Patrushev, N., Hilenski, L., Robert Nazarewicz, R., Ma, M., Ushio-Fukai, M., and Alexander, R. W. (2009). Pgc-1alpha serine570 phosphorylation and gcn5-mediated acetylation by angiotensin ii drive catalase downregulation and vascular hypertrophy. The Journal of biological chemistry. http://www.citeulike.org/user/HEIRS/article/6414356

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Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes.

Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes.