Virgin olive oil and a Mediterranean diet fight heart disease by changing how our genes function

"New research in the FASEB Journal suggests that the polyphenols in virgin olive oil modify the expression of atherosclerosis-related genes, leading to health benefits" Read more....Virgin olive oil and a Mediterranean diet fight heart disease by changing how our genes function:

Mouse Study Sheds Light on Diabetes-Heart Disease Link

"high blood sugar elevates reactive molecules that contain the oxygen atom (called reactive oxygen species) in autonomic neurons. This chemical change inactivates the neurotransmitter receptors at these synapses, they noted." Mouse Study Sheds Light on Diabetes-Heart Disease Link:

Downregulation of the Ornithine System, the Heart and NO-cGMP!

Hypertrophy of cardiomyocytes was induced by AngII, this caused an increase in putrescine, spermidine and total polyamine pool in association with a decreased level of NO. Expressions of eNOS and PKG-I were down-regulated, [Ca2+]i was increased, and expressions of c-Fos and c-Myc upregulated. DFMO reversed these changes induced by AngII.

Lin, Y., Liu, J.-C., Zhang, X.-J., Li, G.-W., Wang, L.-N., Xi, Y.-H., Li, H.-Z., Zhao, Y.-J., and Xu, C.-Q. (2010). Downregulation of the ornithine decarboxylase/polyamine system inhibits angiotensin-induced hypertrophy of cardiomyocytes through the no/cgmp-dependent protein kinase type-i pathway. Cellular Physiology and Biochemistry, 25(4-5).





HEIRS Environmental Illness Research Blog: Dysfunction of Methylation and Nrf2 in Environmental Illness - A Better Explanation than NO/ONOO- ?

Antioxidant Acitvator of Nrf2 Suppresses Angiotensin and Oxidative Stress in the Heart.

Angiotensin is a strong activator of oxidative stress. A new study reports that a chemical compound that activates the Nrf2 system suppresses oxidative stress via angiotensin.

Ichikawa, T., Li, J., Meyer, C. J., Janicki, J. S., Hannink, M., and Cui, T. (2009). Dihydro-cddo-trifluoroethyl amide (dh404), a novel nrf2 activator, suppresses oxidative stress in cardiomyocytes. PloS one, 4(12). http://www.citeulike.org/user/HEIRS/article/6463013

Depression Increases Protein Linked to Heart Disease

Depression Predicts Increases In Inflammatory Protein Linked To Heart Disease

ScienceDaily (2009-10-07) -- Researchers report that depressive symptoms are associated with increases over time in interleukin-6, an inflammatory protein that predicts cardiovascular events. In contrast, levels of interleukin-6 were not related to later increases in depressive symptoms. ... > read full article

Exposure to air pollution can cause heart attack

Exposure to air pollution can cause heart attack