Summary:Angiotensin is a hormone that contributes to conditions such as aging, insulin resistance and cardiovascular disease. PGC-1a is a negative regulator of vascular hypertrophy and H2O2 elevations by upregulating catalase and reducing ROS.
Xiong, S., Salazar, G., San Martin, A., Ahmad, M., Patrushev, N., Hilenski, L., Robert Nazarewicz, R., Ma, M., Ushio-Fukai, M., and Alexander, R. W. (2009). Pgc-1alpha serine570 phosphorylation and gcn5-mediated acetylation by angiotensin ii drive catalase downregulation and vascular hypertrophy. The Journal of biological chemistry. http://www.citeulike.org/user/HEIRS/article/6414356
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