Genetic dissection of systemic autoimmune disease in nrf2 deficient mice.

Title: Genetic dissection of systemic autoimmune disease in nrf2 deficient mice.

Summary: "SLE occurs with an prevalence as high as 1 in 2,500 people but predominantly affects women (35). SLE is especially prevalent in women during their childbearing years (9:1 female to male ratio) and during pregnancy, suggesting a role of female hormones in development of the disease. Most mouse models of SLE also exhibit an increased susceptibility of females to the disease. The sex-specific decreases in glutathione S-transferase -1 and -2 and µ-1, -2, and -3 have been shown previously in the livers of nrf2 knockout mice (10) and are in agreement with our study (Table 3). The findings from this data and other reports strongly suggest that a deficiency in detoxification and increased oxidative stress can result in the development of a systemic autoimmune disease."

Li, J., Stein, T. D., and Johnson, J. A. (2004). Genetic dissection of systemic autoimmune disease in nrf2 deficient mice. Physiological Genomics, pages 1-57.  http://www.citeulike.org/user/HEIRS/article/6012655