Cellular Immune Processes in IBD Activated By Smoke, Burning and More!

"Modulation of AhR signaling pathway via the diet, cessation of smoking, or administration of AhR antagonists could be viable strategies for the treatment of IBD."

Arsenescu, R., Arsenescu, V., Zhong, J., Nasser, M., Melinte, R., Dingle, C. W., Swanson, H., and de Villiers, W. J. (2010). Role of the xenobiotic receptor in inflammatory bowel disease. Inflammatory bowel diseases.
http://www.citeulike.org/user/HEIRS/article/7950224

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis.

"AICAR-initiated AMPK activation may act as a central downregulator in ongoing innate and adaptive immune responses of murine colitis, providing a novel therapeutic approach in the treatment of IBD."

Read more: CiteULike: AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis.:

For further reading: AMPK

Gut Inflammation and Changes in Intestinal Function From Loss of NO Neurons~!

In a recent study the author writes "enteric neurons are supported by glial cells, the ENS counterparts of astrocytes of the CNS, that can modulate enteric neuron function. Enteric neurons are known to control virtually all GI functions, including motility, secretion, blood flow, mucosal growth and aspects of the local immune system. Consequently, permanent or even transient structural alterations in the ENS, as occur in IBD, disrupt normal GI function. Structural changes in the ENS are predictive of disease evolution suggesting that neuroprotection would decrease disease severity and may play a role in recurrence in CD." Further he continues that under conditions of experimental trichinosis infection in the murine "that in this animal model of colitis, there was a significant loss of nitric oxide synthase- (NOS-) immunoreactive neurons in the myenteric plexus of infected rats. Moreover, the selective loss of NOS-positive neurons appears to underlie changes in motility." (Lakhan) Recent reports also suggest that hormones such as serotonin influences gut regulation and may activate inflammatory cytokines in the intestine leading to alterations in gut function. (Khan) Inflammatory activity such as Tnf-a in the periphery such as the gut may influence production of cytokines and changes in gene expression in the brain that change behavior and have other unexpected health effects.




Khan, W. I. and Ghia, J. E. (2010). Gut hormones: emerging role in immune activation and inflammation. Clinical and experimental immunology, 161(1):19-27.
http://www.citeulike.org/user/HEIRS/article/7323747

Lakhan, S. E. and Kirchgessner, A. (2010). Neuroinflammation in inflammatory bowel disease. Journal of neuroinflammation, 7:37+.
http://www.citeulike.org/user/HEIRS/article/7471133

Connections: Hearing Loss and Inflammatory Bowel Disease

CiteULike: Sensorineural Hearing Loss in Pediatric Patients with Inflammatory Bowel Disease: "Sensorineural Hearing Loss in Pediatric Patients with Inflammatory Bowel Disease"

Inflammatory mediator NF-KappaB regulates diarrhea in inflammatory bowel disease

Inflammatory mediator regulates diarrhea in inflammatory bowel disease

ScienceDaily (2009-12-30) -- Researchers have discovered that activation of NK-kappa B, an inflammatory mediator, results in diarrhea in inflammatory bowel disease (IBD). ... > read full article

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Asthma linked to increased risk for IBD in children

Asthma linked to increased risk for IBD in children: "URL: Asthma linked to increased risk for IBD in children

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Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease.

Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease.: "URL: Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease.

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Researchers Unveil Two Genetic Mutations Associated with Early-onset Inflammatory Bowel Disease

Researchers Unveil Two Genetic Mutations Associated with Early-onset Inflammatory Bowel Disease: "URL: Researchers Unveil Two Genetic Mutations Associated with Early-onset Inflammatory Bowel Disease

HEIRS Health & Home
www.heirs-online.com
heirshealth@gmail.com
Check out some of our cool, more eco-friendly, non-toxic or got-to-have items in the HEIRS Web Store at Amazon or specialty items in the HEIRS Store at HEIRS Health & Home.

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