Dysregulated immune balance in lupus.

Our data indicate that the mechanisms involved in balancing Th1 and Th17 regulation, as well as in producing IL-6, are aberrant in SLE, leading to an increased Th17 response.

CiteULike: Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus: "Shah, K., Lee, W. W., Lee, S. H., Kim, S. H., Kang, S. W., Craft, J., and Kang, I. (2010). Dysregulated balance of th17 and th1 cells in systemic lupus erythematosus. Arthritis Research & Therapy, 12(2):R53+."

for pi-3k-dependent migration of th17-polarized cells in response to ccr2 and ccr6 agonists

Webb, A., Johnson, A., Fortunato, M., Platt, A., Crabbe, T., Christie, M. I., Watt, G. F., Ward, S. G., and Jopling, L. A. (2008). Evidence for pi-3k-dependent migration of th17-polarized cells in response to ccr2 and ccr6 agonists. J Leukoc Biol, 84(4):1202-1212. http://www.citeulike.org/user/HEIRS/article/6414025




   

First immunological clue to why some H1N1 patients get very ill or die

First immunological clue to why some H1N1 patients get very ill or die: "URL: First immunological clue to why some H1N1 patients get very ill or die

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Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease.

Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease.: "URL: Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease.

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The nuclear receptor ppargamma selectively inhibits th17 differentiation in a t cell-intrinsic fashion and suppresses cns autoimmunity.

Title: The nuclear receptor ppargamma selectively inhibits th17 differentiation in a t cell-intrinsic fashion and suppresses cns autoimmunity.


Summary: "Suggests PPARgamma represents a promising molecular target for specific immunointervention in Th17-mediated autoimmune diseases such as MS "

Citation: Klotz, L., Burgdorf, S., Dani, I., Saijo, K., Flossdorf, J., Hucke, S., Alferink, J., Novak, N., Beyer, M., Mayer, G., Langhans, B., Klockgether, T., Waisman, A., Eberl, G., Schultze, J., Famulok, M., Kolanus, W., Glass, C., Kurts, C., and Knolle, P. A. (2009). The nuclear receptor ppargamma selectively inhibits th17 differentiation in a t cell-intrinsic fashion and suppresses cns autoimmunity. J. Exp. Med., 206(10):2079-2089. http://www.citeulike.org/user/HEIRS/article/5778777