Showing posts with label influenza. Show all posts
Showing posts with label influenza. Show all posts

Friday, November 26, 2010

Role of oxidative stress on diesel-enhanced influenza infection in mice

"exposure to DE during an influenza infection polarizes the local immune responses to an IL-4 dominated profile in association with increased viral disease, and some aspects of this effect can be reversed with antioxidants."

Read abstract: CiteULike: Role of oxidative stress on diesel-enhanced influenza infection in mice:

Friday, February 19, 2010

Flu-Induced Stress Response Necessary for Resistance to Secondary Illness


Flu-induced stress response is critical for resistance to secondary infection

ScienceDaily (2010-02-19) -- A new study reveals how infection with the influenza virus impacts the way that the immune system responds to subsequent infections. The research provides a new understanding of the physiological and pathological consequences of the flu. ... > read full article

Friday, December 25, 2009

Vaccinating Against Bacterial Infections May Reduce Flu-Related Pneumonia Deaths

Vaccinating Against Bacterial Infections May Reduce Flu-Related Pneumonia Deaths: "URL: Vaccinating Against Bacterial Infections May Reduce Flu-Related Pneumonia Deaths


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Wednesday, September 9, 2009

The AhR and Diseases of the Lung!

Nrf2 is a modulator of inflammatory mediators as well as, interacts with the aryl hydrocarbon (AhR). Neff-Layford suggests that activation of the AhR by pollutants dysregulates IFN-gamma through an iNOS pathway which may lead to a difference in the severity of infection. The author explains further that overproduction of IFN-gamma leads to hyperinflammation in lungs of humans and animals and the levels of IFN-gamma and iNOS correlates with severity of those with acute respiratory distress syndrome. She points out that both influenza and activation of the AhR have been implicated as increasing the severity of these diseases. She concludes that inappropriate activation of the AhR contributes to the severity and complexity of diseases of the lung.

Neff-LaFord, H., Teske, S., Bushnell, T. P., and Lawrence, B. P. (2007). Aryl hydrocarbon receptor activation during influenza virus infection unveils a novel pathway of ifn- production by phagocytic cells1. The Journal of Immunology, 179:247-255 http://www.citeulike.org/user/HEIRS/article/5759129