Endotoxin-induced Enzyme Causes Depressive Symtoms Before Cytokine/NO Production~!

"IDO by direct application of LPS was preceded by synthesis and secretion of TNFalpha and IL-6 protein and activation of iNOS while IFNgamma expression was undetectable."

CiteULike: Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

Insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma.

CiteULike: Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma.: "Fousteri, G., Dave, A., Bot, A., Juntti, T., Omid, S., and von Herrath, M. (2010). Subcutaneous insulin b:9-23/ifa immunisation induces tregs that control late-stage prediabetes in nod mice through il-10 and ifngamma. Diabetologia, 53(9):1958-1970."

Reduced IL-10 and IFN-γ levels linked to polysensitization in children

Reduced IL-10 and IFN-γ levels linked to polysensitization in children: "URL: Reduced IL-10 and IFN-γ levels linked to polysensitization in children

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The AhR and Diseases of the Lung!

Nrf2 is a modulator of inflammatory mediators as well as, interacts with the aryl hydrocarbon (AhR). Neff-Layford suggests that activation of the AhR by pollutants dysregulates IFN-gamma through an iNOS pathway which may lead to a difference in the severity of infection. The author explains further that overproduction of IFN-gamma leads to hyperinflammation in lungs of humans and animals and the levels of IFN-gamma and iNOS correlates with severity of those with acute respiratory distress syndrome. She points out that both influenza and activation of the AhR have been implicated as increasing the severity of these diseases. She concludes that inappropriate activation of the AhR contributes to the severity and complexity of diseases of the lung.

Neff-LaFord, H., Teske, S., Bushnell, T. P., and Lawrence, B. P. (2007). Aryl hydrocarbon receptor activation during influenza virus infection unveils a novel pathway of ifn-
production by phagocytic cells1. The Journal of Immunology, 179:247-255 http://www.citeulike.org/user/HEIRS/article/5759129