Chronic Elevated Ammonia Contributes to Neuroinflammation, Cognitive and Motor Dysfunction.

CiteULike: Hyperammonemia Induces Neuroinflammation that Contributes to Cognitive Impairment in Rats with Hepatic Encephalopathy.: "Chronic moderate hyperammonemia or BDL activated the microglia, especially in cerebellum; increased iNOS, IL-1beta, and prostaglandin E2 levels; and impaired cognitive and motor function, compared with controls"

Mitochondrial MAO Enzyme May Contribute to Oxidative Stress in Hyperammonemia!

brain mitochondrial MAO-A is regulated by the function of NMDA receptors. The enzyme can contribute to the oxidative stress associated with hyperammonemic conditions such as encephalopathy and Alzheimer’s disease.

CiteULike: Brain monoamine oxidase A in hyperammonemia is regulated by NMDA receptors: "Kosenko, E. and Kaminsky, Y. (2009). Brain monoamine oxidase a in hyperammonemia is regulated by nmda receptors. Central European Journal of Biology, 4(3):321-326."