Neuroprotective and Anti-inflammatory Activities of Ketogenic Diet on MPTP-induced Neurotoxicity.

Comments: I believe the results of this study are indicative of the fact that a keen understanding of the patients environmental illness and the factors that lead to it are crucial for the best holistic treatment and management of it. It is obvious that a one size fits treatment plan is probably not in the best interest of most patients.

"The change of dopamine was very similar to dopaminergic neurons in the SN. KD inhibited the activation of microglia induced by MPTP in the SN. The levels of proinflammatory cytokines (interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha) in the SN were also decreased and induced by MPTP. So, we concluded that KD was neuroprotective and anti-inflammatory against MPTP-neurotoxicity."

Read more: CiteULike: Neuroprotective and Anti-inflammatory Activities of Ketogenic Diet on MPTP-induced Neurotoxicity.:

Mitochondrial MAO Enzyme May Contribute to Oxidative Stress in Hyperammonemia!

brain mitochondrial MAO-A is regulated by the function of NMDA receptors. The enzyme can contribute to the oxidative stress associated with hyperammonemic conditions such as encephalopathy and Alzheimer’s disease.

CiteULike: Brain monoamine oxidase A in hyperammonemia is regulated by NMDA receptors: "Kosenko, E. and Kaminsky, Y. (2009). Brain monoamine oxidase a in hyperammonemia is regulated by nmda receptors. Central European Journal of Biology, 4(3):321-326."

Natural Compound In Extra-virgin Olive Oil -- Oleocanthal -- May Help Prevent, Treat Alzheimer's

Natural Compound In Extra-virgin Olive Oil -- Oleocanthal -- May Help Prevent, Treat Alzheimer's

ScienceDaily (2009-09-29) -- Oleocanthal, a naturally-occurring compound in extra-virgin olive oil, alters the structure and increases antibody recognition of neurotoxic proteins associated with Alzheimer's disease. The structural change impedes the proteins' ability to damage brain nerve cells, while increased antibody recognition may enhance immunotherapy-based treatments. The findings suggest that oleocanthal may have potential as a preventative and therapeutic agent for Alzheimer's. ... > read full article

Protein inhibitor helps rid brain of toxic tau protein

Protein inhibitor helps rid brain of toxic tau protein
Inhibiting the protein Hsp70 rapidly reduces brain levels of tau, a protein associated with Alzheimer's disease when it builds up abnormally inside nerve cells affecting memory, neuroscientists at the University of South Florida found. The study is reported online today in the Journal of Neuroscience.

Notes: Polymorphisms in the HSP70 have been associated with disease complications in Alzheimer's, Parkinson's disease and longevity.