Mitochondrial MAO Enzyme May Contribute to Oxidative Stress in Hyperammonemia!

brain mitochondrial MAO-A is regulated by the function of NMDA receptors. The enzyme can contribute to the oxidative stress associated with hyperammonemic conditions such as encephalopathy and Alzheimer’s disease.

CiteULike: Brain monoamine oxidase A in hyperammonemia is regulated by NMDA receptors: "Kosenko, E. and Kaminsky, Y. (2009). Brain monoamine oxidase a in hyperammonemia is regulated by nmda receptors. Central European Journal of Biology, 4(3):321-326."

Chronic Stress and Elevated Norepinephrine - Effects on the Heart

Summary: "enhanced MAO-A activity coupled with increased intramyocardial norepinephrine availability results in increased reactive oxygen species generation which can lead to cardiac dysfunction from chronic stress."


Increased Norepinephrine Breakdown Adverse for Heart. Mpdern Medicine. Retrieved January 14, 2009.

Thimmulappa, R. K., Mai, K. H., Srisuma, S., Kensler, T. W., Yamamoto, M., and Biswal, S. (2002). Identification of nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res, 62(18):5196-5203.
http://www.citeulike.org/user/HEIRS/article/3728059