Health and Environmental Illness Research Blog: December 2009

Thursday, December 31, 2009

Nrf2 and Environmental Pollutants

Summary: The Nrf2 has an important role in detoxification of environmental pollutants. Alterations in Nrf2 function can influence environmentally-induced disease.

Rubio, V., Valverde, M., and Rojas, E. (2009). Effects of atmospheric pollutants on the nrf2 survival pathway. Environmental Science and Pollution Research. http://www.citeulike.org/user/HEIRS/article/4330390

Chronic Fatigue Syndrome is an Metabolic Inflammatory Condition w/ Heart Consequences

Summary: "ME/CFS is a multisystemic metabolic-inflammatory disorder. The aberrations in IO&NS pathways may increase the risk for cardiovascular disorders."

CiteULike: Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.: "Maes, M. and Twisk, F. N. N. (2009). Why myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (io&ns) pathways may explain cardiovascular disorders in me/cfs. Neuro endocrinology letters, 30(6"

Wine Component Reduces Inflammatory Pathway Mediation by Endotoxin

Summary: Resveratrol counteracted LPS effect by decreasing CD14 and IRAK1 expression but unexpectedly increased the p38 MAPK protein phosphorylation. Altogether, our data highlighted the functionality of the TLR4-Myd88 signaling pathway in LPS prooxidant effect using non myeloid cells.

Sebai, H., Ristorcelli, E., Sbarra, V., Hovsepian, S., Fayat, G., Aouani, E., and Lombardo, D. (2009). Protective effect of resveratrol against lps-induced extracellular lipoperoxidation in ar42j cells partly via a myd88-dependent signaling pathway. Archives of biochemistry and biophysics. http://www.citeulike.org/user/HEIRS/article/6457832

Hormone Linked to Panic Attacks Also Linked to Endotoxin and Sickness Behavior

CiteULike: Lipopolysaccharide challenge-induced suppression of Fos in hypothalamic orexin neurons: their potential role in sickness behavior.: "Gaykema, R. P. and Goehler, L. E. (2009). Lipopolysaccharide challenge-induced suppression of fos in hypothalamic orexin neurons: their potential role in sickness behavior. Brain, behavior, and immunity, 23(7):926-930."

Runaway vigilance hormone linked to panic attacks. National Institute of Mental Health. http://www.citeulike.org/user/HEIRS/article/6463151

Epstein Barr: Interesting Interactions With Inflammatory Mediators Implicated in Environmental Illness

Summary: This nuclear translocation of NF-kappaB may promote viral latency by negatively regulating BZLF1 transcriptional activity. In situations where p65 activity is limiting in comparison to BZLF1, the ability of BZLF1 to inhibit p65 transcriptional function may protect the virus from the host immune system during the lytic form of infection.

Morrison, T. E. and Kenney, S. C. (2004). Bzlf1, an epstein-barr virus immediate-early protein, induces p65 nuclear translocation while inhibiting p65 transcriptional function. Virology, 328(2):219-232. http://www.citeulike.org/user/HEIRS/article/6463038

Antioxidant Acitvator of Nrf2 Suppresses Angiotensin and Oxidative Stress in the Heart.

Angiotensin is a strong activator of oxidative stress. A new study reports that a chemical compound that activates the Nrf2 system suppresses oxidative stress via angiotensin.

Ichikawa, T., Li, J., Meyer, C. J., Janicki, J. S., Hannink, M., and Cui, T. (2009). Dihydro-cddo-trifluoroethyl amide (dh404), a novel nrf2 activator, suppresses oxidative stress in cardiomyocytes. PloS one, 4(12). http://www.citeulike.org/user/HEIRS/article/6463013

Cigarette Smoking and Invasive Pneumococcal Disease - Implications for Severity of H1N1

Cigarette smoking is the strongest risk factor for pneumococcal disease among immunocompetant non-elderly people. (Nuorti) As we have noted, cigarette also disrupts the major antioxidant system Nrf2. A recent report has shown that pneumococcal disease makes complications from H1N1 much more severe. Because of the relationship of Nrf2 and its important influence on modulation of inflammatory processes. It is worth suggesting that the dysruption of Nrf2 may contribute to H1N1 infection complications and because there have been polymorphs in Nrf2 identified - these polymorphs may make a person either more at risk or less at risk for complications related to H1N1. The implications of this includes that unless a person understands these risk factors related to their own genetic makeup it is advisable to take a physician's advice that is based on recent knowledge and understanding instead of those who claim to be "experts" in environmental disease.

CiteULike: Cigarette Smoking and Invasive Pneumococcal Disease: "Nuorti, J. P., Butler, J. C., Farley, M. M., Harrison, L. H., McGeer, A., Kolczak, M. S., Breiman, R. F., and Team, T. A. B. C. S. (2000). Cigarette smoking and invasive pneumococcal disease. N Engl J Med, 342(10):681-689."

Tokairin, Y., Shibata, Y., Sata, M., Abe, S., Takabatake, N., Igarashi, A., Ishikawa, T., Inoue, S., and Kubota, I. (2008). Enhanced immediate inflammatory response to streptococcus pneumoniae in the lungs of mice with pulmonary emphysema. Respirology (Carlton, Vic.), 13(3):324-332. http://www.citeulike.org/user/HEIRS/article/2651950

Nuorti, J. P., Butler, J. C., Farley, M. M., Harrison, L. H., McGeer, A., Kolczak, M. S., Breiman, R. F., and Team, T. A. B. C. S. (2000). Cigarette smoking and invasive pneumococcal disease. N Engl J Med, 342(10):681-689. http://www.citeulike.org/user/HEIRS/article/6462894

Reddy, N. M., Suryanarayana, V., Kalvakolanu, D. V., Yamamoto, M., Kensler, T. W., Hassoun, P. M., Kleeberger, S. R., and Reddy, S. P. (2009). Innate immunity against bacterial infection following hyperoxia exposure is impaired in nrf2-deficient mice. J Immunol, 183(7):4601-4608.

Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae. EurekAlert. December 31, 2009. http://www.eurekalert.org/pub_releases/2009-12/cums-soh123009.php

Osteopontin a mediator of cytokine production contributes to allergic contact dermatitis

Osteopontin contributes to allergic contact dermatitis

ScienceDaily (2009-12-30) -- Researchers in Germany have discovered that osteopontin (OPN) contributes to allergic contact dermatitis. ... > read full article

Inflammatory mediator NF-KappaB regulates diarrhea in inflammatory bowel disease

Inflammatory mediator regulates diarrhea in inflammatory bowel disease

ScienceDaily (2009-12-30) -- Researchers have discovered that activation of NK-kappa B, an inflammatory mediator, results in diarrhea in inflammatory bowel disease (IBD). ... > read full article

null

Wednesday, December 30, 2009

Etiological and biological aspects (ie AhR,Th-17) of cigarette smoking in rheumatoid arthritis.

One would suspect that pollutants are a major factor considering involvement with the AhR and this author makes some interesting points that RA started in the New World in the N American population and spread to Europe suggesting a vector-born disease.....??
TENNESSEE ORIGINS OF RHEUMATOID ARTHRITIS by Bruce M. Rothschild

Etiological and biological aspects of cigarette smoking in rheumatoid arthritis.: "Onozaki, K. (2009). Etiological and biological aspects of cigarette smoking in rheumatoid arthritis. Inflammation & allergy drug targets, 8(5):364-368"

Variability in Human Populations of Antioxidant System by Cigarette Smoke

CiteULike: Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking.: "Hübner, R.-H. H., Schwartz, J. D., De Bishnu, P., Ferris, B., Omberg, L., Mezey, J. G., Hackett, N. R., and Crystal, R. G. (2009). Coordinate control of expression of nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking. Molecular medicine (Cambridge, Mass.), 15(7-8):203-219"

Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate

CiteULike: Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate: "Kong, J.-S., Yoo, S.-A., Kim, H.-S., Kim, H. A., Yea, K., Ryu, S.-H., Chung, Y.-J., Cho, C.-S., and Kim, W.-U. (2010). Inhibition of synovial hyperplasia, rheumatoid t cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate. Arthritis & Rheumatism, 62(1):159-170."

Nrf2: The role of (Nrf2) in cytokine production of Il-17, IFN-gamma by CD4+ T cells

CiteULike: The role of nuclear factor erythroid 2-related factor 2 (Nrf2) in cytokine production by CD4+ T cells: "Rockwell, C. E., Fields, P. E., and Klaassen, C. D. (2008). The role of nuclear factor erythroid 2-related factor 2 (nrf2) in cytokine production by cd4+ t cells. FASEB."

Nrf2 Is a Key Transcription Factor That Regulates Antioxidant Defense in Macrophages and Epithelial Cells: Protecting against the Proinflammatory and Oxidizing Effects of Diesel Exhaust Chemicals

CiteULike: Nrf2 Is a Key Transcription Factor That Regulates Antioxidant Defense in Macrophages and Epithelial Cells: Protecting against the Proinflammatory and Oxidizing Effects of Diesel Exhaust Chemicals: "Li, N., Alam, J., Venkatesan, M. I., Eiguren-Fernandez, A., Schmitz, D., Di Stefano, E., Slaughter, N., Killeen, E., Wang, X., Huang, A., Wang, M., Miguel, A. H., Cho, A., Sioutas, C., and Nel, A. E. (2004). Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: Protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J Immunol, 173(5):3467-3481."

CiteULike: Latitudinal variation of immune defense and sickness behavior in the white-crowned sparrow (Zonotrichia leucophrys).

CiteULike: Latitudinal variation of immune defense and sickness behavior in the white-crowned sparrow (Zonotrichia leucophrys).: "Owen-Ashley, N. T., Hasselquist, D., Råberg, L., and Wingfield, J. C. (2008). Latitudinal variation of immune defense and sickness behavior in the white-crowned sparrow (zonotrichia leucophrys). Brain, behavior, and immunity, 22(4):614-625."

Sickness Syndrome: Hormonal, behavioral, and thermoregulatory responses to LPS in captive and free-living white-crowned sparrows

CiteULike: Hormonal, behavioral, and thermoregulatory responses to bacterial lipopolysaccharide in captive and free-living white-crowned sparrows (Zonotrichia leucophrys gambelii).: "Owen-Ashley, N. T., Turner, M., Hahn, T. P., and Wingfield, J. C. (2006). Hormonal, behavioral, and thermoregulatory responses to bacterial lipopolysaccharide in captive and free-living white-crowned sparrows (zonotrichia leucophrys gambelii). Hormones and behavior, 49(1):15-29."

Sickness behaviour pushed too far - the basis of the syndrome seen in severe protozoal, bacterial and viral diseases and post-trauma

CiteULike: Sickness behaviour pushed too far - the basis of the syndrome seen in severe protozoal, bacterial and viral diseases and post-trauma: "Clark, I., Budd, A., and Alleva, L. (2008). Sickness behaviour pushed too far - the basis of the syndrome seen in severe protozoal, bacterial and viral diseases and post-trauma. Malaria Journal, 7(1):208+."

Tuesday, December 29, 2009

CiteULike: Let the sun shine in: effects of ultraviolet radiation on invasive pneumococcal disease risk in Philadelphia, Pennsylvania.

CiteULike: Let the sun shine in: effects of ultraviolet radiation on invasive pneumococcal disease risk in Philadelphia, Pennsylvania.: "White, A. N. N. j., Ng, V., Spain, C. V., Johnson, C. C., Kinlin, L. M., and Fisman, D. N. (2009). Let the sun shine in: effects of ultraviolet radiation on invasive pneumococcal disease risk in philadelphia, pennsylvania. BMC infectious diseases, 9:196+."

Calcium Induces Increases in Peroxisome Proliferator-activated Receptor Î³ Coactivator-1Î± and Mitochondrial Biogenesis by a Pathway Leading to p38 Mitogen-activated Protein Kinase Activation

CiteULike: Pathway Leading to p38 Mitogen-activated Protein Kinase Activation: "Wright, D. C., Geiger, P. C., Han, D.-H., Jones, T. E., and Holloszy, J. O. (2007). Calcium induces increases in peroxisome proliferator-activated receptor Î³ coactivator-1Î± and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activation. Journal of Biological Chemistry, 282(26):18793-18799."

Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial.

CiteULike: Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial.: "Holick, M. F., Lamb, J. J., Lerman, R. H., Konda, V. R., Darland, G., Minich, D. M., Desai, A., Chen, T. C., Austin, M., Kornberg, J., Chang, J.-L. L., Hsi, A., Bland, J. S., and Tripp, M. L. (2009). Hop rho iso-alpha acids, berberine, vitamin d(3) and vitamin k (1) favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial. Journal of bone and mineral metabolism."

Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D.

CiteULike: Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D.: "Bahar-Shany, K., Ravid, A., and Koren, R. (2009). Upregulation of mmp-9 production by tnfalpha in keratinocytes and its attenuation by vitamin d. Journal of cellular physiology, 222(3):729-737."

Vitamin D Helps Inhibit Inflammatory Response in Skin

CiteULike: 20,23-dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-kappaB activity in human keratinocytes.: "Janjetovic, Z., Tuckey, R. C., Nguyen, M. N., Thorpe, E. M., and Slominski, A. T. (2009). 20,23-dihydroxyvitamin d3, novel p450scc product, stimulates differentiation and inhibits proliferation and nf-kappab activity in human keratinocytes. Journal of cellular physiology."

HEIRS Health & Home
www.heirs-online.com
Shops HEIRS Online or HEIRS Amazon!

CiteULike: Inhibition of endogenous hydrogen sulfide synthesis by PAG protects against ethanol-induced gastric damage in the rat.

CiteULike: Inhibition of endogenous hydrogen sulfide synthesis by PAG protects against ethanol-induced gastric damage in the rat.: "Chávez-Piña, A. E. E., Tapia-Álvarez, G. R. R., and Navarrete, A. (2009). Inhibition of endogenous hydrogen sulfide synthesis by pag protects against ethanol-induced gastric damage in the rat. European journal of pharmacology."

CiteULike: Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3Î² Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway

CiteULike: Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3Î² Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway: "Shin, S. M., Cho, I. J., and Kim, S. G. (2009). Resveratrol protects mitochondria against oxidative stress through amp-activated protein kinase-mediated glycogen synthase kinase-3Î² inhibition downstream of poly(adp-ribose)polymerase-lkb1 pathway. Molecular Pharmacology, 76(4):884-895."

CiteULike: Protective effect of resveratrol against LPS-induced extracellular lipoperoxidation in AR42J cells partly via a Myd88-dependent signaling pathway.

CiteULike: Protective effect of resveratrol against LPS-induced extracellular lipoperoxidation in AR42J cells partly via a Myd88-dependent signaling pathway.: "Sebai, H., Ristorcelli, E., Sbarra, V., Hovsepian, S., Fayat, G., Aouani, E., and Lombardo, D. (2009). Protective effect of resveratrol against lps-induced extracellular lipoperoxidation in ar42j cells partly via a myd88-dependent signaling pathway. Archives of biochemistry and biophysics."

CiteULike: B1 cells produce nitric oxide in response to a series of toll-like receptor ligands.

CiteULike: B1 cells produce nitric oxide in response to a series of toll-like receptor ligands.: "Tumurkhuu, G., Koide, N., Dagvadorj, J., Noman, A. S., Khuda, I. I.-E. I., Naiki, Y., Komatsu, T., Yoshida, T., and Yokochi, T. (2009). B1 cells produce nitric oxide in response to a series of toll-like receptor ligands. Cellular immunology."

CiteULike: Pseudomonas aeruginosa Exploits Lipid A and Muropeptides Modification as a Strategy to Lower Innate Immunity during Cystic Fibrosis Lung Infection.

CiteULike: Pseudomonas aeruginosa Exploits Lipid A and Muropeptides Modification as a Strategy to Lower Innate Immunity during Cystic Fibrosis Lung Infection.: "Cigana, C., Curcurù, L., Leone, M. R. R., Ieranò, T., Lorè, N. I. I., Bianconi, I., Silipo, A., Cozzolino, F., Lanzetta, R., Molinaro, A., Bernardini, M. L. L., and Bragonzi, A. (2009). Pseudomonas aeruginosa exploits lipid a and muropeptides modification as a strategy to lower innate immunity during cystic fibrosis lung infection. PloS one, 4(12)."

CiteULike: Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer

CiteULike: Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer: "Erdelyi, I., Levenkova, N., Lin, E. Y., Pinto, J. T., Lipkin, M., Quimby, F. W., and Holt, P. R. (2009). Western-style diets induce oxidative stress and dysregulate immune responses in the colon in a mouse model of sporadic colon cancer. J. Nutr., 139(11):2072-2078"

HEIRS Health & Home
www.heirs-online.com
Shops HEIRS Amazon or HEIRS Store Online!

null

CiteULike: Neuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampus.

CiteULike: Neuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampus.: "Scimemi, A., Tian, H., and Diamond, J. S. (2009). Neuronal transporters regulate glutamate clearance, nmda receptor activation, and synaptic plasticity in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(46):14581-14595."

Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression.

CiteULike: Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression.:

"Kawashima, H., Numakawa, T., Kumamaru, E., Adachi, N., Mizuno, H., Ninomiya, M., Kunugi, H., and Hashido, K. (2009). Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microrna-132 expression. Neuroscience."

LTP mechanisms in the dentate gyrus in vivo: BDNF signaling, translation control, and gene function

Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injury.

CiteULike: Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injury.:

"Shan, Y., Liu, B., Li, L., Chang, N., Li, L., Wang, H., Wang, D., Feng, H., Cheung, C., Liao, M., Cui, T., Sugita, S., and Wan, Q. (2009). Regulation of pink1 by nr2b-containing nmda receptors in ischemic neuronal injury. Journal of neurochemistry, 111(5):1149-1160."

GSK-3b is required for hyperdopamine and d2 receptor-mediated inhibition of synaptic nmda receptor function in the rat prefrontal cortex.

Summary: This study suggests that GSK-3beta is required for the hyperdopamine/D(2) receptor-mediated inhibition of NMDA receptors in the prefrontal neurons and these actions may underlie D(2) receptor-mediated psychostimulant effects and hyperdopamine-dependent behaviors in the brain.Li, Y.-C. C., Xi, D., Roman, J., Huang, Y.-Q. Q., and Gao, W.-J. J. (2009). Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and d2 receptor-mediated inhibition of synaptic nmda receptor function in the rat prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(49):15551-15563. http://www.citeulike.org/user/HEIRS/article/6347607#