Wine Component Reduces Inflammatory Pathway Mediation by Endotoxin

Summary: Resveratrol counteracted LPS effect by decreasing CD14 and IRAK1 expression but unexpectedly increased the p38 MAPK protein phosphorylation. Altogether, our data highlighted the functionality of the TLR4-Myd88 signaling pathway in LPS prooxidant effect using non myeloid cells.

Sebai, H., Ristorcelli, E., Sbarra, V., Hovsepian, S., Fayat, G., Aouani, E., and Lombardo, D. (2009). Protective effect of resveratrol against lps-induced extracellular lipoperoxidation in ar42j cells partly via a myd88-dependent signaling pathway. Archives of biochemistry and biophysics. http://www.citeulike.org/user/HEIRS/article/6457832

Expression of tlr4 and cd14 in the central nervous system (cns) in a mptp mouse model of parkinson's-like disease

Panaro, M. A., Lofrumento, D. D., Saponaro, C., De Nuccio, F., Cianciulli, A., Mitolo, V., and Nicolardi, G. (2008). Expression of tlr4 and cd14 in the central nervous system (cns) in a mptp mouse model of parkinson's-like disease. Immunopharmacology and Immunotoxicology, 30(4):729-740. http://www.citeulike.org/user/HEIRS/article/6389780

Expression of TLR4 and CD14 in the Central Nervous System (CNS) in a MPTP Mouse Model of Parkinson's-Like Disease

Title: Expression of tlr4 and cd14 in the central nervous system (cns) in a mptp mouse model of parkinson's-like disease.

Summary: Results demonstrated an augmented expression of both CD14 and TLR4 in the substantia nigra of mice treated with MPTP in comparison to untreated animals, suggesting that the endotoxin receptors are over expressed in different manner in specific areas of the CNS during Parkinson's-like disease.

Panaro‌, M. A., Lofrumento, D. D., Saponaro‌, C., De Nuccio, F., Cianciulli, A., Mitolo, V., and Nicolardi‌, G. (2008). Expression of tlr4 and cd14 in the central nervous system (cns) in a mptp mouse model of parkinson's-like disease. Immunopharmacology and Immunotoxicology, 30(4):729-740. http://www.citeulike.org/user/HEIRS/article/6334780