The Role of Glycogen Synthase Kinase 3 in Regulating IFN-beta-Mediated IL-10 Production

IL-10 production by IFN-β-stimulated DC was shown to suppress IFN-γ and IL-17 production by myelin oligodendrocyte glycoprotein-specific CD4(+) T cells, and this IL-10-dependent anti-inflammatory effect was enhanced by directly targeting GSK3 in DC.

Wang, H. et al. The role of glycogen synthase kinase 3 in regulating ifn-beta-mediated il-10 production. Journal of immunology (Baltimore, Md. : 1950) (2010). URL http://dx.doi.org/10.4049/jimmunol.1001473. http://www.citeulike.org/user/HEIRS/article/8443481

Surprising find may yield new avenue of treatment for painful herniated discs

"An immune cell known to cause chronic inflammation in autoimmune disorders has been identified as a possible culprit in low back pain associated with herniated discs, according to doctors at Duke University Medical Center."

Read more...Surprising find may yield new avenue of treatment for painful herniated discs:

The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients

"The present study indicates that active SLE appears to exist as an imbalance between Treg and Th17 cells. Correction of this Treg/Th17 imbalance may have therapeutic impact for patients with SLE."

Link: CiteULike: The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients:

Nrf2: The role of (Nrf2) in cytokine production of Il-17, IFN-gamma by CD4+ T cells

CiteULike: The role of nuclear factor erythroid 2-related factor 2 (Nrf2) in cytokine production by CD4+ T cells: "Rockwell, C. E., Fields, P. E., and Klaassen, C. D. (2008). The role of nuclear factor erythroid 2-related factor 2 (nrf2) in cytokine production by cd4+ t cells. FASEB."

First immunological clue to why some H1N1 patients get very ill or die

First immunological clue to why some H1N1 patients get very ill or die

ScienceDaily (2009-12-16) -- Scientists have found the first potential immunological clue of why some people develop severe pneumonia when infected by the pandemic H1N1 virus. ... > read full article

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