Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.

"induction of functional Foxp3(+) iT(reg) cells required coordinated action of the transcriptional regulators Smad1 and Aiolos. Thus, AhR is a potential target through which functional iT(reg) cells could be induced in human autoimmune disorders."

Read more: CiteULike: Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.

:"Gandhi, R., Kumar, D., Burns, E. J., Nadeau, M., Dake, B., Laroni, A., Kozoriz, D., Weiner, H. L., and Quintana, F. J. (2010). Activation of the aryl hydrocarbon receptor induces human type 1 regulatory t cell-like and foxp3(+) regulatory t cells. Nature immunology."

Memory T Cells and IL-10 In Autoreactive Suppression.

We propose the novel concept that a population of memory T cells, which is fully equipped to participate in secondary immune responses upon recognition of a relevant recall antigen, contributes to the maintenance of tolerance under steady-state conditions. 10.1084/jem.20091021

CiteULike: CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function: "Rivino, L., Gruarin, P., Haringer, B., Steinfelder, S., Lozza, L., Steckel, B., Weick, A., Sugliano, E., Jarrossay, D., Kuhl, A. A., Loddenkemper, C., Abrignani, S., Sallusto, F., Lanzavecchia, A., and Geginat, J. (2010). Ccr6 is expressed on an il-10-producing, autoreactive memory t cell population with context-dependent regulatory function. J. Exp. Med., 207(3):565-577."

First immunological clue to why some H1N1 patients get very ill or die

First immunological clue to why some H1N1 patients get very ill or die

ScienceDaily (2009-12-16) -- Scientists have found the first potential immunological clue of why some people develop severe pneumonia when infected by the pandemic H1N1 virus. ... > read full article

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