One would suspect that pollutants are a major factor considering involvement with the AhR and this author makes some interesting points that RA started in the New World in the N American population and spread to Europe suggesting a vector-born disease.....??
TENNESSEE ORIGINS OF RHEUMATOID ARTHRITIS by Bruce M. Rothschild
Etiological and biological aspects of cigarette smoking in rheumatoid arthritis.: "Onozaki, K. (2009). Etiological and biological aspects of cigarette smoking in rheumatoid arthritis. Inflammation & allergy drug targets, 8(5):364-368"
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