Flavonoids May Modulate BDNF and Amyloid In Alzheimer's ~!

"stimulating BDNF and reducing Aβ toxicity by natural flavonols provide a therapeutic implication for treatment of AD."


Hou, Y. et al. Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice. Neuropharmacology 58, 911-920 (2010). URL http://dx.doi.org/10.1016/j.neuropharm.2009.11.002.


Related:
Health and Environmental Illness Blog: Solvents, PAHs and BDNF as a Modulator of TrkB, Anxiety and Nrf2~!

Nrf2's Regulation of NRF1 and Its Influence on NMDA Subunits and Environmental Illness - see comments.

Nrf2 Involved in Fatty Acid Suppression of LPS Inflammation

"our study clearly shows for the first time that, DHA/EPA would induce Nrf2 signaling pathway and that Nrf2 plays a role in DHA/EPA suppression of LPS-induced inflammation."

Read asrac: CiteULike: Role of Nrf2 in Suppressing LPS-induced Inflammation in Mouse Peritoneal Macrophages by Polyunsaturated Fatty Acids Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA).:

Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injury.

CiteULike: Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injury.:

"Shan, Y., Liu, B., Li, L., Chang, N., Li, L., Wang, H., Wang, D., Feng, H., Cheung, C., Liao, M., Cui, T., Sugita, S., and Wan, Q. (2009). Regulation of pink1 by nr2b-containing nmda receptors in ischemic neuronal injury. Journal of neurochemistry, 111(5):1149-1160."