CiteULike: Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells.

CiteULike: Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells.: "gene expression changes induced by dietary phytochemicals SFN and EGCG in Nrf2-deficient mice and in PC-3 cells in vitro demonstrates that the effects of SFN+EGCG could be mediated via concerted modulation of Nrf2 and AP-1 pathways in the prostate."


Nair, S., Barve, A., Khor, T.-O. O., Shen, G.-X. X., Lin, W., Chan, J. Y., Cai, L., and Kong, A.-N. N. (2010). Regulation of nrf2- and ap-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of nrf2-knockout or c57bl/6j mice and pc-3 ap-1 human prostate cancer cells. Acta pharmacologica Sinica.  http://www.citeulike.org/user/HEIRS/article/7694509

Tumor Necrosis Factor-Induced Neutrophil Adhesion Occurs Through SphK-1 Activation of Integrin

"TNFalpha activated endothelial cells being sphingosine kinase-1, alpha5beta1, and angiopoietin-2 dependent. Moreover, this work supports the notion that sphingosine kinase-1 may be the single target required for an effective broad spectrum approach to combat inflammation and immune disorders."

Tumor Necrosis Factor-Induced Neutrophil Adhesion ... [Am J Pathol. 2010] - PubMed result:

Researchers explain why red wine and green tea stop prostate cancer growth

"prostate cancer cell lines and mouse models to demonstrate that treatment with these dietary agents results in inhibition of the sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway."
Researchers explain why red wine and green tea stop prostate cancer growth

Polyphenols In Red Wine And Green Tea Halt Prostate Cancer Growth

"In what could lead to a major advance in the treatment of prostate cancer, scientists now know exactly why polyphenols in red wine and green tea inhibit cancer growth. This new discovery, published online in The FASEB Journal, explains how antioxidants in red wine and green tea produce a combined effect to disrupt an important cell signaling pathway necessary for prostate cancer growth."


Polyphenols In Red Wine And Green Tea Halt Prostate Cancer Growth:

Green Tea Activates Reexpression of Glutathione Via Methylation Mechanisms.

New study demonstrates that green tea polyphenols (GTP) has dual potential to alter DNA methylation and chromatin modeling and reexpression of glutathione transferase, the 2 global epigenetic mechanisms of gene regulation and their lack of toxicity makes them excellent candidates for the chemoprevention of prostate cancer.

CiteULike: Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells.: "Pandey, M., Shukla, S., and Gupta, S. (2010). Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of gstp1 in human prostate cancer cells. International journal of cancer. Journal international du cancer, 126(11):2520-2533."

Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer

CiteULike: Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice: "S. Yu, T. O. Khor, K.-L. Cheung, W. Li, T.-Y. Wu, Y. Huang, B. A. Foster, Y. W. Kan, and A.-N. Kong, PLoS ONE 5, e8579+ (2010), URL http://dx.doi.org/10.1371/journal.pone.0008579."


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2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Fibroblast Growth Factor 10-Induced Prostatic Bud Formation in Mouse Urogenital Sinus

2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Fibroblast Growth Factor 10-Induced Prostatic Bud Formation in Mouse Urogenital Sinus

Broccoli May Have Benefits for Prostate Cancer

Title: Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (tramp) mice: implication of induction of nrf2, ho-1 and apoptosis and the suppression of akt-dependent kinase pathway.

Summary: "broccoli sprouts can serve as a good dietary source of SFN in vivo and that they have significant inhibitory effects on prostate tumorigenesis."

Keum, Y.-S. S., Khor, T. O. O., Lin, W., Shen, G., Kwon, K. H. H., Barve, A., Li, W., and Kong, A.-N. N. (2009). Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (tramp) mice: implication of induction of nrf2, ho-1 and apoptosis and the suppression of akt-dependent kinase pathway. Pharmaceutical research, 26(10):2324-2331. http://www.citeulike.org/user/HEIRS/article/5518692