Broccoli Compound Activates Heat Shock Proteins in Addition to Nrf2

"heat shock response by SFN, in addition to the antioxidant response mediated by the Keap1-Nrf2 pathway, may contribute to cytoprotection."

Read more: CiteULike: Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27:

Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation

Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation: "URL: Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation

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More on TLR4 and LPS

Youn, H. S. S., Kim, Y. S. S., Park, Z. Y. Y., Kim, S. Y. Y., Choi, N. Y. Y., Joung, S. M. M., Seo, J. A., Lim, K.-M. M., Kwak, M.-K. K., Hwang, D. H., and Lee, J. Y. Y. (2009). Sulforaphane suppresses oligomerization of tlr4 in a thiol-dependent manner. Journal of immunology (Baltimore, Md. : 1950). http://www.citeulike.org/user/HEIRS/article/6334999

Yamawaki, Y., Kimura, H., Hosoi, T., and Ozawa, K. (2009). Myd88 plays a key role in lps-induced stat3 activation in the hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology. http://www.citeulike.org/user/HEIRS/article/6334989

Chhikara, M., Wang, S., Kern, S. J., Ferreyra, G. A., Barb, J. J., Munson, P. J., and Danner, R. L. (2009). Carbon monoxide blocks lipopolysaccharide-induced gene expression by interfering with proximal tlr4 to nf-kappab signal transduction in human monocytes. PloS one, 4(12). http://www.citeulike.org/user/HEIRS/article/6334984

Dessing, M. C., Hirst, R. A., de Vos, A. F., and van der Poll, T. (2009). Role of toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice. PloS one, 4(11). http://www.citeulike.org/user/HEIRS/article/6334977

Effect of sulforaphane on glutathione-adduct formation and on glutathione_s_transferase-dependent detoxification of acrylamide in caco-2 cells.

Summary: The data suggest that SFN might impair the GSH-dependent detoxification of AA by SFN-GSH adduct formation and, thus, lower the GSH concentrations available for its reaction with AA

Pernice, R., Hauder, J., Koehler, P., Vitaglione, P., Fogliano, V., and Somoza, V. (2009). Effect of sulforaphane on glutathione-adduct formation and on glutathione_s_transferase-dependent detoxification of acrylamide in caco-2 cells. Molecular Nutrition & Food Research, 9999(9999):NA+. http://www.citeulike.org/user/HEIRS/article/6100240

Broccoli May Have Benefits for Prostate Cancer

Title: Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (tramp) mice: implication of induction of nrf2, ho-1 and apoptosis and the suppression of akt-dependent kinase pathway.

Summary: "broccoli sprouts can serve as a good dietary source of SFN in vivo and that they have significant inhibitory effects on prostate tumorigenesis."

Keum, Y.-S. S., Khor, T. O. O., Lin, W., Shen, G., Kwon, K. H. H., Barve, A., Li, W., and Kong, A.-N. N. (2009). Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (tramp) mice: implication of induction of nrf2, ho-1 and apoptosis and the suppression of akt-dependent kinase pathway. Pharmaceutical research, 26(10):2324-2331. http://www.citeulike.org/user/HEIRS/article/5518692