HO-1, Nrf2 in Induction of NRF-1 and Mitochondrial Biogenesis!

"endogenous carbon monoxide (CO) generated by HO-1 overexpression stimulates superoxide dismutase-2 upregulation and mitochondrial H2O2 production, which activates Akt/PKB. Akt deactivates glycogen synthase kinase-3β, which permits Nrf2 nuclear translocation and occupancy of 4 antioxidant response elements (AREs) in the NRF-1 promoter. The ensuing accumulation of nuclear NRF-1 protein leads to gene activation for mitochondrial biogenesis,"

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1 -- Piantadosi et al. 103 (11): 1232 -- Circulation Research:

More on TLR4 and LPS

Youn, H. S. S., Kim, Y. S. S., Park, Z. Y. Y., Kim, S. Y. Y., Choi, N. Y. Y., Joung, S. M. M., Seo, J. A., Lim, K.-M. M., Kwak, M.-K. K., Hwang, D. H., and Lee, J. Y. Y. (2009). Sulforaphane suppresses oligomerization of tlr4 in a thiol-dependent manner. Journal of immunology (Baltimore, Md. : 1950). http://www.citeulike.org/user/HEIRS/article/6334999

Yamawaki, Y., Kimura, H., Hosoi, T., and Ozawa, K. (2009). Myd88 plays a key role in lps-induced stat3 activation in the hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology. http://www.citeulike.org/user/HEIRS/article/6334989

Chhikara, M., Wang, S., Kern, S. J., Ferreyra, G. A., Barb, J. J., Munson, P. J., and Danner, R. L. (2009). Carbon monoxide blocks lipopolysaccharide-induced gene expression by interfering with proximal tlr4 to nf-kappab signal transduction in human monocytes. PloS one, 4(12). http://www.citeulike.org/user/HEIRS/article/6334984

Dessing, M. C., Hirst, R. A., de Vos, A. F., and van der Poll, T. (2009). Role of toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice. PloS one, 4(11). http://www.citeulike.org/user/HEIRS/article/6334977

Carbon monoxide differentially inhibits tlr signaling pathways by regulating ros-induced trafficking of tlrs to lipid rafts.

HEIRS Environmental Illness Research Blog: Why Endotoxin Can Increase Pain,Chemical and Mold Sensitivity and Causes Sickness Behavior!

Nakahira, K., Kim, H. P., Geng, X. H., Nakao, A., Wang, X., Murase, N., Drain, P. F., Wang, X., Sasidhar, M., Nabel, E. G., Takahashi, T., Lukacs, N. W., Ryter, S. W., Morita, K., and Choi, A. M. K. (2006). Carbon monoxide differentially inhibits tlr signaling pathways by regulating ros-induced trafficking of tlrs to lipid rafts. J. Exp. Med., 203(10):2377-2389. http://www.citeulike.org/user/HEIRS/article/6013733



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Prenatal exposure to BPA might explain aggressive behavior in some 2-year-old girls

Prenatal exposure to BPA might explain aggressive behavior in some 2-year-old girls