WOW! I think studies have demonstrated that NRF-1 is important in its regulation with PGC-1a for mitochondrial biogenesis and regulated by Nrf2. This further supports the importance of Nrf2 in environmental disease especially those that have been associated with folate deficiency! We noted another study that broccoli has a role in regulating folate which supports the need for proper Nrf2 function.
CiteULike: The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1 (NRF-1).: "identify NRF-1 as a major inducible transcriptional regulator of PCFT gene expression. The implications of this linkage between folate transport and metabolism with mitochondria biogenesis and respiration are discussed"
Showing posts with label NRF-1. Show all posts
Showing posts with label NRF-1. Show all posts
Saturday, August 21, 2010
Monday, June 21, 2010
HO-1, Nrf2 in Induction of NRF-1 and Mitochondrial Biogenesis!
"endogenous carbon monoxide (CO) generated by HO-1 overexpression stimulates superoxide dismutase-2 upregulation and mitochondrial H2O2 production, which activates Akt/PKB. Akt deactivates glycogen synthase kinase-3β, which permits Nrf2 nuclear translocation and occupancy of 4 antioxidant response elements (AREs) in the NRF-1 promoter. The ensuing accumulation of nuclear NRF-1 protein leads to gene activation for mitochondrial biogenesis,"
Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1 -- Piantadosi et al. 103 (11): 1232 -- Circulation Research:
Wednesday, February 3, 2010
Altered Metabolism, Toxicity, Glutamate Dehydrogenase and NRF-1 and Its Activator PGC-1
Background: NRF-1 binding sites include ornithine decarboxylase and glutamate dehydrogenase through ADP Ribose in humans. Since NRF-1 associates with PGC-1a and Nrf2 -- I think one could suggest it elevates its importance in conditions possibly for those known to fall under the umbrella of environmental illness.
Definition:
****PFC: Perfluorinated compounds (PFCs) refer to a class of organofluorine compounds that have all hydrogens replaced with fluorine on a carbon chain—but also contain at least one different atom or functional group and persist as persistent organic compounds.
The two most studied PFCs are:
**********PFOA or perfluorooctanoic acid, used to make fluoropolymers such as Teflon, among other applications.
**********PFOS or perfluorooctanesulfonic acid, used in the semiconductor industry, 3M's former Scotchgard formulation, and 3M's former fire-fighting foam mixture.
In a recent report, PFC from blood samples from loggerhead turtles were high enough that suggested liver damage and suppression of at least one immune function. (ScienceDaily: 2/22/08)
Quote for the day: I may not be a turtle but I am human....
I mentioned the article above because interestingly, I found articles related to similar chemicals found in products in human home environments including our textiles, upholstery, carpets etc including perfluorooctanoic acid (PFOA) and similar to those found in turtles like those mentioned above. Chemicals such as these may influence the regulation of genes for amino acid metabolism...including those that overlap for methionine and glumate including GLUD1 (glutamate dehydrogenase in rats) and GLUL (glutamate ammonia ligase). "PFOA alters genes in wild-type mouse liver through PPAR alpha and a subset of genes are regulated by CAR and possibly PPAR gamma in the PPAR alpha-null mouse." As Corton explains, nuclear receptors can regulate nutrient and xenobiotic transport and metabolism and stress resistance and that "PGC-1 and PGC-1ß regulate the ligand-dependent and -independent activation of a large number of nuclear receptors including PPAR and constitutive activated receptor (CAR)." This would suggest that conditions that alter the expression of PGC-1a/PGC-1b may synergistically influence or oppose expression of these genes. From this one could propose these interactions may contribute to symptoms associated with environmental illness such as behavioral and mood changes or possibly even chemical sensitivity. These are chemicals that have been found in newborns and past studies show that PFOA cause tumors and are associated with developmental toxicity at high doses although admittedly, the health effects of these chemicals are mostly unknown.(ScienceDaily)
Rosso, L., Marques, A. C., Reichert, A. S., and Kaessmann, H. (2008). Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydroge nase driven by positive darwinian selection. PLoS genetics, 4(8).
http://www.citeulike.org/user/HEIRS/article/3108334
MacMullen, C., Fang, J., Hsu, B. Y., Kelly, A., de Lonlay-Debeney, P., Saudubray, J. M., Ganguly, A., Smith, T. J., Stanley, C. A., and Hyperinsulinism/hyperammonemia Contributing Investigators (2001). Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase. The Journal of clinical endocrinology and metabolism, 86(4):1782-1787. http://www.citeulike.org/user/HEIRS/article/6623806
Virbasius, C.-m. A., Virbasius, J. V., and Scarpulla, R. C. (1993). Nrf-1, an activator involved in nuclearmitochondrial interactions, utilizes a new dna-binding domain conserved in a family of developmental regulators. Genes & Development. http://www.citeulike.org/user/HEIRS/article/6623819
Hossain, M. B., Ji, P., Anish, R., Jacobson, R. H., and Takada, S. (2009). Poly(adp-ribose) polymerase 1 interacts with nuclear respiratory factor 1 (nrf-1) and plays a role in nrf-1 transcriptional regulation. Journal of Biological Chemistry, 284(13):8621-8632. http://www.citeulike.org/user/HEIRS/article/6623948
Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., Wolberger, C., Prolla, T. A., Weindruch, R., Alt, F. W., and Guarente, L. (2006). Sirt4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell, 126(5):941-954. http://www.citeulike.org/user/HEIRS/article/6623971
Rosen, M.B., Lee, J.S., Ren, H., Vallanat, B., Liu, J., Waalkes, M.P., Abbott, B.D., Lau, C., and Corton, J.C. (2008). Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: Evidence for the involvement of nuclear receptors pparalpha and car. Toxicol. Sci., 103(1):46-56. http://www.citeulike.org/user/HEIRS/article/6608986
Corton, J. C. and Brown-Borg, H. M. (2005). Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity. J Gerontol A Biol Sci Med Sci, 60(12):1494-1509. http://www.citeulike.org/user/HEIRS/article/2339648?show_msg=already_posted
Definition:
****PFC: Perfluorinated compounds (PFCs) refer to a class of organofluorine compounds that have all hydrogens replaced with fluorine on a carbon chain—but also contain at least one different atom or functional group and persist as persistent organic compounds.
The two most studied PFCs are:
**********PFOA or perfluorooctanoic acid, used to make fluoropolymers such as Teflon, among other applications.
**********PFOS or perfluorooctanesulfonic acid, used in the semiconductor industry, 3M's former Scotchgard formulation, and 3M's former fire-fighting foam mixture.
In a recent report, PFC from blood samples from loggerhead turtles were high enough that suggested liver damage and suppression of at least one immune function. (ScienceDaily: 2/22/08)
Quote for the day: I may not be a turtle but I am human....
I mentioned the article above because interestingly, I found articles related to similar chemicals found in products in human home environments including our textiles, upholstery, carpets etc including perfluorooctanoic acid (PFOA) and similar to those found in turtles like those mentioned above. Chemicals such as these may influence the regulation of genes for amino acid metabolism...including those that overlap for methionine and glumate including GLUD1 (glutamate dehydrogenase in rats) and GLUL (glutamate ammonia ligase). "PFOA alters genes in wild-type mouse liver through PPAR alpha and a subset of genes are regulated by CAR and possibly PPAR gamma in the PPAR alpha-null mouse." As Corton explains, nuclear receptors can regulate nutrient and xenobiotic transport and metabolism and stress resistance and that "PGC-1 and PGC-1ß regulate the ligand-dependent and -independent activation of a large number of nuclear receptors including PPAR and constitutive activated receptor (CAR)." This would suggest that conditions that alter the expression of PGC-1a/PGC-1b may synergistically influence or oppose expression of these genes. From this one could propose these interactions may contribute to symptoms associated with environmental illness such as behavioral and mood changes or possibly even chemical sensitivity. These are chemicals that have been found in newborns and past studies show that PFOA cause tumors and are associated with developmental toxicity at high doses although admittedly, the health effects of these chemicals are mostly unknown.(ScienceDaily)
Rosso, L., Marques, A. C., Reichert, A. S., and Kaessmann, H. (2008). Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydroge nase driven by positive darwinian selection. PLoS genetics, 4(8).
http://www.citeulike.org/user/HEIRS/article/3108334
MacMullen, C., Fang, J., Hsu, B. Y., Kelly, A., de Lonlay-Debeney, P., Saudubray, J. M., Ganguly, A., Smith, T. J., Stanley, C. A., and Hyperinsulinism/hyperammonemia Contributing Investigators (2001). Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase. The Journal of clinical endocrinology and metabolism, 86(4):1782-1787. http://www.citeulike.org/user/HEIRS/article/6623806
Virbasius, C.-m. A., Virbasius, J. V., and Scarpulla, R. C. (1993). Nrf-1, an activator involved in nuclearmitochondrial interactions, utilizes a new dna-binding domain conserved in a family of developmental regulators. Genes & Development. http://www.citeulike.org/user/HEIRS/article/6623819
Hossain, M. B., Ji, P., Anish, R., Jacobson, R. H., and Takada, S. (2009). Poly(adp-ribose) polymerase 1 interacts with nuclear respiratory factor 1 (nrf-1) and plays a role in nrf-1 transcriptional regulation. Journal of Biological Chemistry, 284(13):8621-8632. http://www.citeulike.org/user/HEIRS/article/6623948
Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., Wolberger, C., Prolla, T. A., Weindruch, R., Alt, F. W., and Guarente, L. (2006). Sirt4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell, 126(5):941-954. http://www.citeulike.org/user/HEIRS/article/6623971
Rosen, M.B., Lee, J.S., Ren, H., Vallanat, B., Liu, J., Waalkes, M.P., Abbott, B.D., Lau, C., and Corton, J.C. (2008). Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: Evidence for the involvement of nuclear receptors pparalpha and car. Toxicol. Sci., 103(1):46-56. http://www.citeulike.org/user/HEIRS/article/6608986
Corton, J. C. and Brown-Borg, H. M. (2005). Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity. J Gerontol A Biol Sci Med Sci, 60(12):1494-1509. http://www.citeulike.org/user/HEIRS/article/2339648?show_msg=already_posted
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