The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF.
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Showing posts with label TNFR1. Show all posts
Showing posts with label TNFR1. Show all posts
Friday, September 25, 2009
Sunday, September 6, 2009
TNFR1, TRPV1 and Inflammation.
Title: Reactive oxygen species mediate tnfr1 increase after trpv1 activation in mouse drg neurons.
Summary: It has been demonstrated the TNFR1 receptor is important for neuroinflammatory responses by MCP-1 and TNFR2 and Nf-kappaB signaling are important to antagonize TNFR1 signal-induced apoptosis. (Marchetti) Ma et al explains how Tnf-a causes nociceptive responses through TNFR1 activation. This study shows TNFR1 and ROS is absent in mice deficient of TRPV1. The conclusions from this study were that TRPV1 activation increases the TNFR1 receptor in culture DRG neurons through a ROS signaling pathway that can lead to pain generation during inflammation.
Notes:
Related Posts:
Citations: Ma, F., Zhang, L., and Westlund, K. N. (2009). Reactive oxygen species mediate tnfr1 increase after trpv1 activation in mouse drg neurons. Molecular pain, 5(1):31+. http://www.citeulike.org/user/HEIRS/article/4934284
Ding, B., Kirkiles-Smith, N. C., and Pober, J. S. (2009). Foxo3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. J. Biol. Chem., 284(29):19331-19339. http://www.citeulike.org/user/HEIRS/article/5725120
Pradillo, J., Hurtado, O., Romera, C., Cardenas, A., Fernandeztome, P., Alonsoescolano, D., Lorenzo, P., Moro, M., and Lizasoain, I. (2006). Tnfr1 mediates increased neuronal membrane eaat3 expression after in vivo cerebral ischemic preconditioning. Neuroscience, 138(4):1171-1178. http://www.citeulike.org/user/HEIRS/article/5699676
Marchetti, L., Klein, M., Schlett, K., Pfizenmaier, K., and Eisel, U. L. (2004). Tumor necrosis factor (tnf)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by n-methyl-d-aspartate receptor activation: Essential role of a tnf receptor 2-mediated phosphatidylinositol 3-kinase-dependent nf-kappab pathway. J. Biol. Chem., 279(31):32869-32881. http://www.citeulike.org/user/HEIRS/article/4080104
Hu, X., Roberts, J. R., Apopa, P. L., Kan, Y. W., and Ma, Q. (2006). Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in nrf2 null mice. 3:940-954. http://www.citeulike.org/user/HEIRS/article/5725231
Summary: It has been demonstrated the TNFR1 receptor is important for neuroinflammatory responses by MCP-1 and TNFR2 and Nf-kappaB signaling are important to antagonize TNFR1 signal-induced apoptosis. (Marchetti) Ma et al explains how Tnf-a causes nociceptive responses through TNFR1 activation. This study shows TNFR1 and ROS is absent in mice deficient of TRPV1. The conclusions from this study were that TRPV1 activation increases the TNFR1 receptor in culture DRG neurons through a ROS signaling pathway that can lead to pain generation during inflammation.
Notes:
- Foxo3a controls the increased expression of TNFR2 which prevents Tnf-mediated apoptosis (programmed cell death). (Ding)
- Foxo3a is decreased in Nrf2 null mice. (Hu)
Related Posts:
Citations: Ma, F., Zhang, L., and Westlund, K. N. (2009). Reactive oxygen species mediate tnfr1 increase after trpv1 activation in mouse drg neurons. Molecular pain, 5(1):31+. http://www.citeulike.org/user/HEIRS/article/4934284
Ding, B., Kirkiles-Smith, N. C., and Pober, J. S. (2009). Foxo3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. J. Biol. Chem., 284(29):19331-19339. http://www.citeulike.org/user/HEIRS/article/5725120
Pradillo, J., Hurtado, O., Romera, C., Cardenas, A., Fernandeztome, P., Alonsoescolano, D., Lorenzo, P., Moro, M., and Lizasoain, I. (2006). Tnfr1 mediates increased neuronal membrane eaat3 expression after in vivo cerebral ischemic preconditioning. Neuroscience, 138(4):1171-1178. http://www.citeulike.org/user/HEIRS/article/5699676
Marchetti, L., Klein, M., Schlett, K., Pfizenmaier, K., and Eisel, U. L. (2004). Tumor necrosis factor (tnf)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by n-methyl-d-aspartate receptor activation: Essential role of a tnf receptor 2-mediated phosphatidylinositol 3-kinase-dependent nf-kappab pathway. J. Biol. Chem., 279(31):32869-32881. http://www.citeulike.org/user/HEIRS/article/4080104
Hu, X., Roberts, J. R., Apopa, P. L., Kan, Y. W., and Ma, Q. (2006). Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in nrf2 null mice. 3:940-954. http://www.citeulike.org/user/HEIRS/article/5725231
Friday, September 4, 2009
Antioxidant System Regulates Aging Genes and Loss Can Lead To Cell Death!
MCP-1 neuroinflammatory processes are dependant on TNFR1. FOXO3a increases the activity of the TNFR2 promoter. Knock-down of the TNFR2 sensitizes microvascular endothelial cells to the activities of TNFR1 mediated apoptosis (programmed cell death). Endothelial dysfunction has been implicated as an important factor in the symptoms of many environmental diseases. FOXO3a is decreased in Nrf2 deficient cells. Other studies have identified FOXO3a as an important regulator of lifespan and aging. In ovarian cells, it has been shown that Nrf2 serves as a sensor and protects against harmful chemicals through a variety of ways including FOXO3a expression. Decreased Nrf2 will lead to a reduction of the FOXO3a modulation of TNFR2and consequentely may increase TNFR1-mediated apoptosis.
Ding, B., Kirkiles-Smith, N. C., and Pober, J. S. (2009). Foxo3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. J. Biol. Chem., 284(29):19331-19339. http://www.citeulike.org/user/HEIRS/article/5725120?updated=1252114581
GenAge for FOXO3.
Hu, X., Roberts, J. R., Apopa, P. L., Kan, Y. W., and Ma, Q. (2006). Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in nrf2 null mice. 3:940-954. http://www.citeulike.org/user/HEIRS/article/5725231
Ding, B., Kirkiles-Smith, N. C., and Pober, J. S. (2009). Foxo3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. J. Biol. Chem., 284(29):19331-19339. http://www.citeulike.org/user/HEIRS/article/5725120?updated=1252114581
GenAge for FOXO3.
Hu, X., Roberts, J. R., Apopa, P. L., Kan, Y. W., and Ma, Q. (2006). Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in nrf2 null mice. 3:940-954. http://www.citeulike.org/user/HEIRS/article/5725231
Tuesday, September 1, 2009
HEIRS Environmental Illness Research Blog: Sickness Syndrome, CFS, Fibromyalgia, IL-10 and HO-1
HEIRS Environmental Illness Research Blog: Sickness Syndrome, CFS, Fibromyalgia, IL-10 and HO-1
Activation of MCP-1/CCl2/CCR2 by TNF-a to cause microglial neuroinflammation and alterations in neurotransmission require the presence of the TNFR1. (D' Mello) The Nrf2 pathway has been shown to modulate inflammatory mediators including Tnf-a and the glutamate antiporter system. (Lewerenz) The TNFR1 receptor is important for preconditioning in ischemia to reduce injury from subsequent ischemia through interaction with the EAAT3. The EAAT3 transporter regulates glutamate and also is involved with glutathione synthesis and is present in cortical and striatal neurons. (Suchak) It works cooperatively with xCT to prevent depletion of glutathione caused by high glutamate levels and may be useful in eventual therapy for Parkinson's. (Lewerenz)
D'Mello, C., Le, T., and Swain, M. G. (2009). Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J. Neurosci., 29(7):2089-2102. http://www.citeulike.org/user/HEIRS/article/4079736
Suchak, S. K., Baloyianni, N. V., Perkinton, M. S., Williams, R. J., Meldrum, B. S., and Rattray, M. (2003). The 'glial' glutamate transporter, eaat2 (glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. Journal of neurochemistry, 84(3):522-532. Suchak, S. K., Baloyianni, N. V., Perkinton, M. S., Williams, R. J., Meldrum, B. S., and Rattray, M. (2003). The 'glial' glutamate transporter, eaat2 (glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. Journal of neurochemistry, 84(3):522-532. http://www.citeulike.org/user/HEIRS/article/5699931
Pradillo, J., Hurtado, O., Romera, C., Cardenas, A., Fernandeztome, P., Alonsoescolano, D., Lorenzo, P., Moro, M., and Lizasoain, I. (2006). Tnfr1 mediates increased neuronal membrane eaat3 expression after in vivo cerebral ischemic preconditioning. Neuroscience, 138(4):1171-1178. http://www.citeulike.org/user/HEIRS/article/5699676
Lewerenz, J., Klein, M., and Methner, A. (2006). Cooperative action of glutamate transporters and cystine/glutamate antiporter system xc- protects from oxidative glutamate toxicity. Journal of neurochemistry, 98(3):916-925. http://www.citeulike.org/user/HEIRS/article/762845
Lewerenz, J., Albrecht, P., Tien, M.-L. T. L., Henke, N., Karumbayaram, S., Kornblum, H. I., Wiedau-Pazos, M., Schubert, D., Maher, P., and Methner, A. (2009). Induction of nrf2 and xct are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. Journal of neurochemistry. http://www.citeulike.org/user/HEIRS/article/5627214
Maher, P., Lewerenz, J., Lozano, C., and Torres, J. L. L. (2008). A novel approach to enhancing cellular glutathione levels. Journal of neurochemistry, 107(3):690-700.
http://www.citeulike.org/user/HEIRS/article/3401858
Activation of MCP-1/CCl2/CCR2 by TNF-a to cause microglial neuroinflammation and alterations in neurotransmission require the presence of the TNFR1. (D' Mello) The Nrf2 pathway has been shown to modulate inflammatory mediators including Tnf-a and the glutamate antiporter system. (Lewerenz) The TNFR1 receptor is important for preconditioning in ischemia to reduce injury from subsequent ischemia through interaction with the EAAT3. The EAAT3 transporter regulates glutamate and also is involved with glutathione synthesis and is present in cortical and striatal neurons. (Suchak) It works cooperatively with xCT to prevent depletion of glutathione caused by high glutamate levels and may be useful in eventual therapy for Parkinson's. (Lewerenz)
D'Mello, C., Le, T., and Swain, M. G. (2009). Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J. Neurosci., 29(7):2089-2102. http://www.citeulike.org/user/HEIRS/article/4079736
Suchak, S. K., Baloyianni, N. V., Perkinton, M. S., Williams, R. J., Meldrum, B. S., and Rattray, M. (2003). The 'glial' glutamate transporter, eaat2 (glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. Journal of neurochemistry, 84(3):522-532. Suchak, S. K., Baloyianni, N. V., Perkinton, M. S., Williams, R. J., Meldrum, B. S., and Rattray, M. (2003). The 'glial' glutamate transporter, eaat2 (glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. Journal of neurochemistry, 84(3):522-532. http://www.citeulike.org/user/HEIRS/article/5699931
Pradillo, J., Hurtado, O., Romera, C., Cardenas, A., Fernandeztome, P., Alonsoescolano, D., Lorenzo, P., Moro, M., and Lizasoain, I. (2006). Tnfr1 mediates increased neuronal membrane eaat3 expression after in vivo cerebral ischemic preconditioning. Neuroscience, 138(4):1171-1178. http://www.citeulike.org/user/HEIRS/article/5699676
Lewerenz, J., Klein, M., and Methner, A. (2006). Cooperative action of glutamate transporters and cystine/glutamate antiporter system xc- protects from oxidative glutamate toxicity. Journal of neurochemistry, 98(3):916-925. http://www.citeulike.org/user/HEIRS/article/762845
Lewerenz, J., Albrecht, P., Tien, M.-L. T. L., Henke, N., Karumbayaram, S., Kornblum, H. I., Wiedau-Pazos, M., Schubert, D., Maher, P., and Methner, A. (2009). Induction of nrf2 and xct are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. Journal of neurochemistry. http://www.citeulike.org/user/HEIRS/article/5627214
Maher, P., Lewerenz, J., Lozano, C., and Torres, J. L. L. (2008). A novel approach to enhancing cellular glutathione levels. Journal of neurochemistry, 107(3):690-700.
http://www.citeulike.org/user/HEIRS/article/3401858
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