TNFR1, TRPV1 and Inflammation.

Title: Reactive oxygen species mediate tnfr1 increase after trpv1 activation in mouse drg neurons.

Summary: It has been demonstrated the TNFR1 receptor is important for neuroinflammatory responses by MCP-1 and TNFR2 and Nf-kappaB signaling are important to antagonize TNFR1 signal-induced apoptosis. (Marchetti) Ma et al explains how Tnf-a causes nociceptive responses through TNFR1 activation. This study shows TNFR1 and ROS is absent in mice deficient of TRPV1. The conclusions from this study were that TRPV1 activation increases the TNFR1 receptor in culture DRG neurons through a ROS signaling pathway that can lead to pain generation during inflammation.

Notes:

• Foxo3a controls the increased expression of TNFR2 which prevents Tnf-mediated apoptosis (programmed cell death). (Ding)   
• Foxo3a is decreased in Nrf2 null mice. (Hu)

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Citations: Ma, F., Zhang, L., and Westlund, K. N. (2009). Reactive oxygen species mediate tnfr1 increase after trpv1 activation in mouse drg neurons. Molecular pain, 5(1):31+. http://www.citeulike.org/user/HEIRS/article/4934284
Ding, B., Kirkiles-Smith, N. C., and Pober, J. S. (2009). Foxo3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. J. Biol. Chem., 284(29):19331-19339. http://www.citeulike.org/user/HEIRS/article/5725120
Pradillo, J., Hurtado, O., Romera, C., Cardenas, A., Fernandeztome, P., Alonsoescolano, D., Lorenzo, P., Moro, M., and Lizasoain, I. (2006). Tnfr1 mediates increased neuronal membrane eaat3 expression after in vivo cerebral ischemic preconditioning. Neuroscience, 138(4):1171-1178. http://www.citeulike.org/user/HEIRS/article/5699676
Marchetti, L., Klein, M., Schlett, K., Pfizenmaier, K., and Eisel, U. L. (2004). Tumor necrosis factor (tnf)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by n-methyl-d-aspartate receptor activation: Essential role of a tnf receptor 2-mediated phosphatidylinositol 3-kinase-dependent nf-kappab pathway. J. Biol. Chem., 279(31):32869-32881. http://www.citeulike.org/user/HEIRS/article/4080104
Hu, X., Roberts, J. R., Apopa, P. L., Kan, Y. W., and Ma, Q. (2006). Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in nrf2 null mice. 3:940-954. http://www.citeulike.org/user/HEIRS/article/5725231