'the present study provides a novel mechanism wherein the reduced oxidative stress in heat-shocked hyperglycemic cells down-regulates Glut-1 and glucose uptake, and fine-tuning of this pathway may be a potential approach to use for therapeutic benefit of diabetes mellitus."
Presley, T., Vedam, K., Druhan, L. J. & Ilangovan, G. Hyperthermia-induced Hsp90·eNOS Preserves Mitochondrial Respiration in Hyperglycemic Endothelial Cells by Down-regulating Glut-1 and Up-regulating G6PD Activity. Journal of Biological Chemistry 285, 38194-38203 (2010). URL http://dx.doi.org/10.1074/jbc.M110.147728. http://www.citeulike.org/user/HEIRS/article/8399736
HEIRS Library Tags: Hsp90
Showing posts with label NADPH oxidase. Show all posts
Showing posts with label NADPH oxidase. Show all posts
Thursday, December 9, 2010
Friday, October 29, 2010
Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase
Comment: I may forgetting something -- but this might be a possible benefit of polyphenols from red wine in combatting some of the effects of cigarette smoke and combustable pollutants?
Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase
Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase
Tuesday, September 1, 2009
Angiotensin, CAMKII and ROS
HEIRS Environmental Illness Research Blog: Fibromyalgia, Endoplasmic Reticulum Stress, Neurotoxicity and CAMKII
Activation of the angiotensin system which may lead to generation of NADPH oxidase and ROS. The NADPH oxidase system is the major source of ROS generation from angiotensin and exaggerates ROS production from the mitochondria. Li demonstrates that angiotensin stimulates CAMKII, H2O2 production release of arachidonic acid and subsequent Akt activation induced by phospholipase 2.
Zhang, G.-X. X., Lu, X.-M. M., Kimura, S., and Nishiyama, A. (2007). Role of mitochondria in angiotensin ii-induced reactive oxygen species and mitogen-activated protein kinase activation. Cardiovasc Res. http://www.citeulike.org/user/HEIRS/article/1643746
Li, F. and Malik, K. U. (2005). Angiotensin ii-induced akt activation is mediated by metabolites of arachidonic acid generated by camkii-stimulated ca2+-dependent phospholipase a2. Am J Physiol Heart Circ Physiol, 288(5):H2306-2316. http://www.citeulike.org/user/HEIRS/article/4626324
Activation of the angiotensin system which may lead to generation of NADPH oxidase and ROS. The NADPH oxidase system is the major source of ROS generation from angiotensin and exaggerates ROS production from the mitochondria. Li demonstrates that angiotensin stimulates CAMKII, H2O2 production release of arachidonic acid and subsequent Akt activation induced by phospholipase 2.
Zhang, G.-X. X., Lu, X.-M. M., Kimura, S., and Nishiyama, A. (2007). Role of mitochondria in angiotensin ii-induced reactive oxygen species and mitogen-activated protein kinase activation. Cardiovasc Res. http://www.citeulike.org/user/HEIRS/article/1643746
Li, F. and Malik, K. U. (2005). Angiotensin ii-induced akt activation is mediated by metabolites of arachidonic acid generated by camkii-stimulated ca2+-dependent phospholipase a2. Am J Physiol Heart Circ Physiol, 288(5):H2306-2316. http://www.citeulike.org/user/HEIRS/article/4626324
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