Hyperthermia-induced Hsp90·eNOS Preserves Mitochondrial Respiration in Hyperglycemic EC by Down-regulating Glut-1 and Up-regulating G6PD Activity

'the present study provides a novel mechanism wherein the reduced oxidative stress in heat-shocked hyperglycemic cells down-regulates Glut-1 and glucose uptake, and fine-tuning of this pathway may be a potential approach to use for therapeutic benefit of diabetes mellitus."

Presley, T., Vedam, K., Druhan, L. J. & Ilangovan, G. Hyperthermia-induced Hsp90·eNOS Preserves Mitochondrial Respiration in Hyperglycemic Endothelial Cells by Down-regulating Glut-1 and Up-regulating G6PD Activity. Journal of Biological Chemistry 285, 38194-38203 (2010). URL http://dx.doi.org/10.1074/jbc.M110.147728.  http://www.citeulike.org/user/HEIRS/article/8399736

HEIRS Library Tags: Hsp90

Adequate Regulation of G6PD Levels May Help Treat Diabetes.

"Researchers identified a protein (G6PD protein) and its antioxidant product (NAPDH) that both prevent the death and promote the growth of cells which produce and release insulin in the pancreas (beta cells)."

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