Angiotensin, CAMKII and ROS

HEIRS Environmental Illness Research Blog: Fibromyalgia, Endoplasmic Reticulum Stress, Neurotoxicity and CAMKII

Activation of the angiotensin system which may lead to generation of NADPH oxidase and ROS. The NADPH oxidase system is the major source of ROS generation from angiotensin and exaggerates ROS production from the mitochondria. Li demonstrates that angiotensin stimulates CAMKII, H2O2 production release of arachidonic acid and subsequent Akt activation induced by phospholipase 2.

Zhang, G.-X. X., Lu, X.-M. M., Kimura, S., and Nishiyama, A. (2007). Role of mitochondria in angiotensin ii-induced reactive oxygen species and mitogen-activated protein kinase activation. Cardiovasc Res. http://www.citeulike.org/user/HEIRS/article/1643746
Li, F. and Malik, K. U. (2005). Angiotensin ii-induced akt activation is mediated by metabolites of arachidonic acid generated by camkii-stimulated ca2+-dependent phospholipase a2. Am J Physiol Heart Circ Physiol, 288(5):H2306-2316. http://www.citeulike.org/user/HEIRS/article/4626324