Acupuncture Gets Military Support For Gulf War Illness Treatment

"The Department of Defense has made a $1.2 million research grant to the New England School of Acupuncture (located in Newton, Massachusetts). The goal of the study is to determine the effectiveness of acupuncture in the treatment of Gulf War Illness (GWI)."

Acupuncture Gets Military Support For Gulf War Illness Treatment:

FOXP3(+) CD4(+) Tregs lose suppressive potential but remain anergic during transient inflammation in human.

A loss of the suppressive function of Tregs have been implicated as a possible contributor to chemical sensitivity. This new study suggests that inflammation can cause a loss of Tregs suppressive function. This suggests that periods where inflammation is higher may contribute to chemical sensitivity.

Read Abstract: CiteULike: FOXP3(+) CD4(+) Tregs lose suppressive potential but remain anergic during transient inflammation in human.: "European journal of immunology (9 February 2011) doi:10.1002/eji.201040363 Key: citeulike:8982549"

CiteULike: Isothiocyanates Reduce Mercury Accumulation via an Nrf2-Dependent Mechanism during Exposure of Mice to Methylmercury.

Compound in broccoli can help prevent toxicity from mercury exposure.

"Environmental health perspectives (7 March 2011) doi:10.1289/ehp.1003123 Key: citeulike:8979952"

CiteULike: Isothiocyanates Reduce Mercury Accumulation via an Nrf2-Dependent Mechanism during Exposure of Mice to Methylmercury.:

Pfizer Touts New Drug for Fibromyalgia, Critics Warn Consumers

"Pfizer’s new television commercial for the medication Lyrica, features a middle-aged woman who says that her Fibromyalgia (FMS) is real and that she can now live without pain thanks to the medication"

Read more: Kalamazoo Shopper::Complete Article:

FDA cracks down on untested cold medicines - BusinessWeek

"The Food and Drug Administration says it will remove roughly 500 unapproved cold and allergy medications from the market as part of an ongoing campaign cracking down on ineffective prescription medications."

Read more: FDA cracks down on untested cold medicines - BusinessWeek:

A brain MRI study of chronic fatigue syndrome: Evidence of brainstem dysfunction and altered homeostasis [preview] – Source: NMR in Biomedicine, March 2011

New study suggests that astrocyte dysfunction may play a role in chronic fatigue issue.

A brain MRI study of chronic fatigue syndrome: Evidence of brainstem dysfunction and altered homeostasis [preview] – Source: NMR in Biomedicine, March 2011: "A brain MRI study of chronic fatigue syndrome: Evidence of brainstem dysfunction and altered homeostasis [preview] – Source: NMR in Biomedicine, March 2011"

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Researchers Discover Biological Pathway Linked to PTSD - ABC News

"In both men and women with PTSD, the PAC1 gene was more likely to be modified by a process call 'methylation,' meaning people are not necessarily born susceptible to PTSD but can acquire the vulnerability over time. The finding supports the idea that environmental, genetic and so-called epigenetic factors all contribute to PTSD risk"

Watch:



Read more: Researchers Discover Biological Pathway Linked to PTSD - ABC News:

Genetic switch that controls tissue regeneration found

I have written extensively about the Nrf2 antioxidant system and how it influences overall health, especially in response to environmental contaminants and controllng free radical injury. Looks like research now shows it may influence stem cells too!

"It is well known that human body has the ability to heal itself. Thanks to the presence of stem cells, many organs can undergo continuous renewal. But this activity of stem cells has to be carefully controlled, as too much activity can cause diseases like cancer."

Read more: Genetic switch that controls tissue regeneration found:

Analysis of common and specific mechanisms of liver function affected by nitrotoluene compounds.

A common chemical used in industry and medicine causes alterations in a number of pathways that may contribute to environmental-illness-like symptoms. Long-term exposure may contribute to injury.

"PloS one, Vol. 6, No. 2. (2011) doi:10.1371/journal.pone.0014662 Key: citeulike:8887114"

Read abstract:CiteULike: Analysis of common and specific mechanisms of liver function affected by nitrotoluene compounds.:


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High Cholesterol, Blood Pressure Linked to Early Memory Loss - AOL Health

"New research finds that high cholesterol and high blood pressure not only put patients at risk for heart disease but are also risk factors for early memory loss and other cognitive problems"

Read more:High Cholesterol, Blood Pressure Linked to Early Memory Loss - AOL Health:

Higher Levels of Pain Intensity in Multiple Chemical Sensitvity -Says Study

"this is the first study to show facilitated pain processing in MCS and EC patients with the most abnormal responses in MCS"

The Clinical journal of pain, Vol. 27, No. 2. (February 2011), pp. 156-162. Key: citeulike:8774097


Read more: CiteULike: Increased capsaicin-induced secondary hyperalgesia in patients with multiple chemical sensitivity.:

Recommended: Chemical Sensitivity: A Guide to Coping With Hypersensitivity Syndrome, Sick Building Syndrome and Other Environmental Illnesses

Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons.

"that AhR opposingly regulates NMDA receptor-mediated excitotoxicity and neurotrophism possibly by differentially regulating the expression of synaptic and extrasynaptic NMDA receptors."

Read more: CiteULike: Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons.:

BDNF, LRRK and Pink and Environment Play Role in Parkinson's Disease~!

"PD risk is modulated by both genetic factors including BDNF, PINK, and LRRK and environmental exposures."

Read more: CiteULike: Lrrk2 S1647T and BDNF V66M interact with environmental factors to increase risk of Parkinson's disease.:

Cellular mechanism responsible for chronic inflammation, type 2 diabetes uncovered

Cellular mechanism responsible for chronic inflammation, type 2 diabetes uncovered

Reduction of Signalling of GSK-3B May Reduce Some Problems in Non-alcoholic Liver Disease~!

High fat diets may caugment environmental illness by disrupting processes in a variety of pathways such as the Nrf2 and contributes to a variety of patholgies including non-alcoholic liver disease. GSK-3b is a protein that can serve as an "on-off switch" for the antioxidant system. A new study shows that knock-down of this protein may provide cells with more resistance to some of the damaging effects of saturated fats in the diet.

 Ibrahim, S. H. et al. Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. Journal of hepatology (2010). URL http://dx.doi.org/10.1016/j.jhep.2010.09.039. http://www.citeulike.org/user/HEIRS/article/8365324

The Role of Glycogen Synthase Kinase 3 in Regulating IFN-beta-Mediated IL-10 Production

IL-10 production by IFN-β-stimulated DC was shown to suppress IFN-γ and IL-17 production by myelin oligodendrocyte glycoprotein-specific CD4(+) T cells, and this IL-10-dependent anti-inflammatory effect was enhanced by directly targeting GSK3 in DC.

Wang, H. et al. The role of glycogen synthase kinase 3 in regulating ifn-beta-mediated il-10 production. Journal of immunology (Baltimore, Md. : 1950) (2010). URL http://dx.doi.org/10.4049/jimmunol.1001473. http://www.citeulike.org/user/HEIRS/article/8443481

Cells' Natural Defence Against Cancer-Causing Viruses Discovered

Cells' Natural Defence Against Cancer-Causing Viruses Discovered

Compound With Potent Effects on the Biological Clock Discovered

Using automated screening techniques developed by pharmaceutical companies to find new drugs, researchers from UC San Diego and three other research institutions have discovered a molecule with the most potent effects ever seen on the biological clock. Dubbed "longdaysin," for its ability to dramatically slow down the biological clock...

Read more: Compound With Potent Effects on the Biological Clock Discovered

Proteins in Bone Health, Development and Disease in Environmental Illness

Proteins in Bone Health, Development and Disease in Environmental Illness

Study: Polymorphisms in Cytokines May Contribute to Autoimmune Disease in Canadian Aboriginal Populations~!

This has implications for conditions where methylation and polymorphisms that effect control of cytokines as well, including the Nrf2 pathway!


Larcombe, L. et al. Differential cytokine genotype frequencies among Canadian Aboriginal and Caucasian populations. Genes and Immunity 6, 140-144 (2004). URL http://dx.doi.org/10.1038/sj.gene.6364157.