Reduction of Signalling of GSK-3B May Reduce Some Problems in Non-alcoholic Liver Disease~!

High fat diets may caugment environmental illness by disrupting processes in a variety of pathways such as the Nrf2 and contributes to a variety of patholgies including non-alcoholic liver disease. GSK-3b is a protein that can serve as an "on-off switch" for the antioxidant system. A new study shows that knock-down of this protein may provide cells with more resistance to some of the damaging effects of saturated fats in the diet.

 Ibrahim, S. H. et al. Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. Journal of hepatology (2010). URL http://dx.doi.org/10.1016/j.jhep.2010.09.039. http://www.citeulike.org/user/HEIRS/article/8365324

AhR and NF-E2-related factor 2 are key regulators of human MRP4 expression

Our findings indicate that AhR and Nrf2 play important roles in regulating MRP4 expression and suggest that agents that activate their activity may be of therapeutic benefit for cholestasis.

CiteULike: Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression: "Xu, S., Weerachayaphorn, J., Cai, S.-Y., Soroka, C. J., and Boyer, J. L. (2010). Aryl hydrocarbon receptor and nf-e2-related factor 2 are key regulators of human mrp4 expression. Am J Physiol Gastrointest Liver Physiol, 299(1):G126-135."

Stomach Hormone Called Ghrelin Mitigates Liver Fibrosis

Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis: "Ghrelin, a stomach hormone, reduced the amount of fibrogenic cells by 25% in the treated rodents. Research further showed ghrelin prevented acute liver damage and reduced oxidative stress and inflammation in the animal models."

Curcumin helps prevent hepatic fibrosis through suppression of oxLDL

Curcumin helps prevent hepatic fibrosis through suppression of oxLDL