Our findings indicate that AhR and Nrf2 play important roles in regulating MRP4 expression and suggest that agents that activate their activity may be of therapeutic benefit for cholestasis.
CiteULike: Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression: "Xu, S., Weerachayaphorn, J., Cai, S.-Y., Soroka, C. J., and Boyer, J. L. (2010). Aryl hydrocarbon receptor and nf-e2-related factor 2 are key regulators of human mrp4 expression. Am J Physiol Gastrointest Liver Physiol, 299(1):G126-135."
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