Dioxins: bioaccumulatives chemical compounds formed through combustion and manufacturing. Incidents include backyard burning, applications of herbicides, wastewater treatment, coal-fires, diesel trucks, cigarette smoke, etc(Wipedia)
A recent study shows "activation of Ahr2/Arnt1 pathway by TCDD and BNF affects the shape of certain blood vessels in the brain of developing zebrafish." Past studies have demonstrated a significant impact of AhR signaling on the immune system that may also alter the Nrf2 antioxidant system. For this reason, we have suggested an important relationship of AhR and Nrf2 signaling in environmental illness and alterations of blood flow may be a factor in environmental illness symptoms. Dinatale showed AhR signaling initiates an inflammatory cascade that includes Il-6 via Il-1 and NF-kappaB and present in autoimmune and chronic proliferative diseases.
CiteULike: Malformation of certain brain blood vessels caused by TCDD activation of Ahr2/Arnt1 signaling in developing zebrafish.:
Teraoka, H., Ogawa, A., Kubota, A., Stegeman, J. J., Peterson, R. E., and Hiraga, T. (2010). Malformation of certain brain blood vessels caused by tcdd activation of ahr2/arnt1 signaling in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands).
http://www.citeulike.org/user/HEIRS/article/7149860
Dinatale, B. C., Schroeder, J. C., Francey, L. J., Kusnadi, A., and Perdew, G. H. (2010). Mechanistic insights into the events that lead to synergistic induction of il6 transcription upon activation of the ah receptor and inflammatory signaling. The Journal of biological chemistry.
http://www.citeulike.org/user/HEIRS/article/7339715
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