Study Says Lean Neurotoxicity Not Generated By Nitric Oxide But Gene Expression Changes~! Interesting.....

Background: Heavy metals are ubiquitous in the environment and especially found in particulate matter, jewelry and in dust especially in older homes.

In this study the expression patterns of nitric oxide synthases at the mRNA and protein levels, however, were not significantly altered by treatment with 10 mg/kg Pb. These findings indicate that Pb-induced neurotoxicity may be modulated in part by the expression of Ddah1, Sod1, Ccs, and Sfn in the olfactory bulb.

CiteULike: Effects of Lead Exposure on Nitric Oxide-associated Gene Expression in the Olfactory Bulb of Mice.: "Kim, S., Hyun, J., Kim, H., Kim, Y., Kim, E., Jang, J., and Kim, K. (2010). Effects of lead exposure on nitric oxide-associated gene expression in the olfactory bulb of mice. Biological trace element research."