Study Says Lean Neurotoxicity Not Generated By Nitric Oxide But Gene Expression Changes~! Interesting.....

Background: Heavy metals are ubiquitous in the environment and especially found in particulate matter, jewelry and in dust especially in older homes.

In this study the expression patterns of nitric oxide synthases at the mRNA and protein levels, however, were not significantly altered by treatment with 10 mg/kg Pb. These findings indicate that Pb-induced neurotoxicity may be modulated in part by the expression of Ddah1, Sod1, Ccs, and Sfn in the olfactory bulb.

CiteULike: Effects of Lead Exposure on Nitric Oxide-associated Gene Expression in the Olfactory Bulb of Mice.: "Kim, S., Hyun, J., Kim, H., Kim, Y., Kim, E., Jang, J., and Kim, K. (2010). Effects of lead exposure on nitric oxide-associated gene expression in the olfactory bulb of mice. Biological trace element research."

Heavy Metals Elevates Antioxidant Capacity to Combat Oxidative Stress in Mine Workers~!

"Taken together, the results indicate that exposure to combination of Pb and Zn in mine elevates total antioxidant capacity of body in a reflex to overcome to oxidative stress. Especially, in the present case, it seems that toxic effect of Pb has been greater than positive effects of Zn, but the combination exposure has resulted in not such a critical toxicity situation."

CiteULike: Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workers: