Flaxseed Oil May Protect Against Lead Toxicity~!

"flaxseed oil is a natural product can be protect against lead acetate-mediated hepatic cytotoxicity

Read abstract: CiteULike: The Redox Status in Rats Treated with Flaxseed Oil and Lead-Induced Hepatotoxicity.:."

Study Says Lean Neurotoxicity Not Generated By Nitric Oxide But Gene Expression Changes~! Interesting.....

Background: Heavy metals are ubiquitous in the environment and especially found in particulate matter, jewelry and in dust especially in older homes.

In this study the expression patterns of nitric oxide synthases at the mRNA and protein levels, however, were not significantly altered by treatment with 10 mg/kg Pb. These findings indicate that Pb-induced neurotoxicity may be modulated in part by the expression of Ddah1, Sod1, Ccs, and Sfn in the olfactory bulb.

CiteULike: Effects of Lead Exposure on Nitric Oxide-associated Gene Expression in the Olfactory Bulb of Mice.: "Kim, S., Hyun, J., Kim, H., Kim, Y., Kim, E., Jang, J., and Kim, K. (2010). Effects of lead exposure on nitric oxide-associated gene expression in the olfactory bulb of mice. Biological trace element research."

Heavy Metals, Metallothionein and Regulation by Nrf2

Metallothionein: protein that modulates internal stores of heavy metals. Alterations in function have been recently implicated in autism as well as, other conditions where metals may be a factor including metabolic impairments and Alzheimer's.

In several past blogs, we have discussed health benefits of broccoli because it elevates the Nrf2 antioxidant system. In contrast to the preceding blog where it was noted that metallothioneins can inhibit GSK-3b which is an off/on switch for Nrf2 it has also be demonstrated that metalloproteins can be regulated by Nrf2. In 2005, Yeh's study suggested that sulphoraphane, "strongly suggest that at low concentrations of sulforaphane, activation of MAPKs such as ERK and p38 pathway lead to Nrf2-mediated metallothionein gene expression." One can assume from this that conditions that impair the Nrf2 system may lead to possible accumulation of toxic amounts of metals that can impair any number of metabolic processes. Such conditions include methylation, nutrition and other genetic factors such as polymorphisms, for example. Of course, this does not exclude factors that impair metallothionein on its own.

Notes:

• metallothionein expression needs to be tightly regulated because underexpression or overexpression can help mitigte or enhance disease.

HEIRS Library Tags: heavy metals, sulphoraphane (sulforaphane), Nrf2*****Sign up to receive alerts of heavy metal articles

            Blog Tags: Broccoli, sulforaphane, Nrf2

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Raymond, A. D., Gekonge, B., Giri, M. S., Hancock, A., Papasavvas, E., Chehimi, J., Kossevkov, A. V., Nicols, C., Yousef, M., Mounzer, K., Shull, J., Kostman, J., Showe, L., and Montaner, L. J. (2010). Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during hiv viremia. Journal of leukocyte biology.

http://www.citeulike.org/user/HEIRS/article/7369487


Yeh, C.-T. and Yen, G.-C. (2005). Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma hepg2 cells. Carginogenesis Advance Access.

http://www.citeulike.org/user/HEIRS/article/7369321

Sabolić, I., Breljak, D., Skarica, M., and Herak-Kramberger, C. M. (2010). Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.

http://www.citeulike.org/user/HEIRS/article/7369302

Heavy Metals Elevates Antioxidant Capacity to Combat Oxidative Stress in Mine Workers~!

"Taken together, the results indicate that exposure to combination of Pb and Zn in mine elevates total antioxidant capacity of body in a reflex to overcome to oxidative stress. Especially, in the present case, it seems that toxic effect of Pb has been greater than positive effects of Zn, but the combination exposure has resulted in not such a critical toxicity situation."

CiteULike: Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workers:

Ascorbic Acid May Prevent Lead-Induced Hypertension via Nitric Oxide!

"ascorbic acid as an antioxidant prevents the lead induced hypertension. This effect may be mediated by inhibition of NOc oxidation and thereby increasing availability of NO."

Effect of ascorbic acid supplementation on nitric oxide metabolites and systolic blood pressure in rats exposed to lead Mohammad A, Ali N, Reza B, Ali K - Indian J Pharmacol:

Exposure to Metal-rich Particulate Matter Modifies the Expression of Candidate MicroRNAs in Peripheral Blood Leukocytes

CiteULike: Exposure to Metal-rich Particulate Matter Modifies the Expression of Candidate MicroRNAs in Peripheral Blood Leukocytes: "Bollati, V., Marinelli, B., Apostoli, P., Bonzini, M., Nordio, F., Hoxha, M., Pegoraro, V., Motta, V., Tarantini, L., Cantone, L., Schwartz, J., Bertazzi, P. A., and Baccarelli, A. (2010). Exposure to metal-rich particulate matter modifies the expression of candidate micrornas in peripheral blood leukocytes. Environmental Health Perspectives."

Higher Blood Lead Levels Associated With Depression, Panic Disorder In Young Adults With Low Levels Of Lead Exposure

Higher Blood Lead Levels Associated With Depression, Panic Disorder In Young Adults With Low Levels Of Lead Exposure: "URL: Higher Blood Lead Levels Associated With Depression, Panic Disorder In Young Adults With Low Levels Of Lead Exposure

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Nitrogen Dioxide, Ozone & Lead Partner to Increase Pollution Dangers to Urban Children

The adverse health effects of ozone (O3) and nitrogen dioxide (NO2) have been known for decades. The Clean Air Act was established in 1963, but ambient a quality was not regulated until 1970, and by 1971 EPA had established one hour National Ambient Air Quality Standard (NAAQS) of 0.08 ppm for both O3 and nitrogen dioxide.

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Dura Coat Products, Inc., Joins EPA’s National Partnership for Environmental Priorities

Company commits to reducing lead chromate and polycyclic aromatic compounds from paint formulations. Click here.

"Safe" Threshold For Blood Lead Levels In Children Is Harmful To Their Central Nervous System

"Safe" Threshold For Blood Lead Levels In Children Is Harmful To Their Central Nervous System

Lead in bone associated with increased risk of death from cardiovascular disease in men

Lead in bone associated with increased risk of death from cardiovascular disease in men