Previously we noted that the estrogen signalling may influence expression of Nrf2 enzymes. A new study provides support that estrogen may provide some protection against LPS exposure effects. It has been noted by a number of researchers the sexual dimorphism that occurs with environmental conditions including CFS, FM and MCS and this relationship could provide a mechanism for the significantly higher prevalence of some EI conditions in women especially as they get older.
"these studies identify a dramatic cytokine- and chemokine-mediated neuroinflammatory response that is regulated through ERalpha- and ERbeta-mediated ligand-dependent and ligand-independent mechanisms"
Read more: CiteULike: Production of Proinflammatory Cytokines and Chemokines During Neuroinflammation: Novel Roles for Estrogen Receptors alpha and beta:
Supplemental Resource: Yao, Y., Brodie, A. M., Davidson, N. E., Kensler, T. W., and Zhou, Q. (2010). Inhibition of estrogen signaling activates the nrf2 pathway in breast cancer. Breast cancer research and treatment. http://www.citeulike.org/user/HEIRS/article/7493023?show_msg=already_posted
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