Essential role of ER-alpha-dependent NO production... [Am J Physiol Heart Circ Physiol. 2010] - PubMed result

Well....well!  More evidence of sexual dimorphism.....????


Essential role of ER-alpha-dependent NO production... [Am J Physiol Heart Circ Physiol. 2010] - PubMed result: "These data thus suggest that RESV inhibits vascular proliferative responses after injury, predominately through an ER-alpha-dependent increase in NO production."

Estrogen's Influence on Neuroinflammation May Explain Sex Differences in Environmental Illness.

Previously we noted that the estrogen signalling may influence expression of Nrf2 enzymes. A new study provides support that estrogen may provide some protection against LPS exposure effects. It has been noted by a number of researchers the sexual dimorphism that occurs with environmental conditions including CFS, FM and MCS and this relationship could provide a mechanism for the significantly higher prevalence of some EI conditions in women especially as they get older.

"these studies identify a dramatic cytokine- and chemokine-mediated neuroinflammatory response that is regulated through ERalpha- and ERbeta-mediated ligand-dependent and ligand-independent mechanisms"

Read more: CiteULike: Production of Proinflammatory Cytokines and Chemokines During Neuroinflammation: Novel Roles for Estrogen Receptors alpha and beta:

Supplemental Resource: Yao, Y., Brodie, A. M., Davidson, N. E., Kensler, T. W., and Zhou, Q. (2010). Inhibition of estrogen signaling activates the nrf2 pathway in breast cancer. Breast cancer research and treatment. http://www.citeulike.org/user/HEIRS/article/7493023?show_msg=already_posted