PBDE (flame retardents), dioxins, PCBs etc bioaccumulate in fat tissue. One study shows that agents that cause ER stress result in failure of preadipocyte differentiation, failure to accumulate lipid, inhibit PPAR-gamma and adiponectin and resulted in sustained synthesis of MCP-1. (MCP-1 is associated with sickness syndrome.) Other agents that inhibited GATA during the study seemed to do the same. Suggesting that agents that cause ER stress may inhibit GATA and cause these changes. Adiponecting and PPAR-gamma are both anti-inflammatory regulators.
Shimada, T., Hiramatsu, N., Okamura, M., Hayakawa, K., Kasai, A., Yao, J., and Kitamura, M. (2007). Unexpected blockade of adipocyte differentiation by k-7174: Implication for endoplasmic reticulum stress. Biochemical and Biophysical Research Communications, 363(2):355-360. http://www.citeulike.org/user/HEIRS/article/5436816
No comments:
Post a Comment